Manifestation of automaticity in the pulmonary-vein myocardium of rats with abdominal aorto-venocaval shunt

Journal of Pharmacological Sciences
Shogo HamaguchiHikaru Tanaka

Abstract

Effect of abdominal aorto-venocaval shunt (AVS) on the automaticity of the pulmonary-vein myocardium was studied in the rat. Spontaneous electrical activity was observed in one third of the isolated pulmonary-vein preparations from the AVS rats, but scarcely in those from sham-operated rats; the activity was induced by tertiapin and suppressed by carbachol or chelation of intracellular Ca(2+). The evoked action potentials in AVS rats had less negative resting membrane potential and longer action potential duration than those in sham-operated rats. These results suggest that the automaticity of the rat pulmonary-vein myocardium is manifested under chronic volume overload.

References

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Sep 3, 1998·The New England Journal of Medicine·M HaïssaguerreJ Clémenty
Jun 20, 2007·Basic & Clinical Pharmacology & Toxicology·Akira TakaharaKeitaro Hashimoto
Jul 13, 2012·Journal of Pharmacological Sciences·Yayoi TsuneokaHikaru Tanaka
Jan 11, 2013·Biological & Pharmaceutical Bulletin·Iyuki NamekataHikaru Tanaka
Sep 23, 2014·Journal of Pharmacological Sciences·Akira TakaharaHikaru Tanaka

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