Manifestation of Clinical Categories of Ocular Graft-versus-Host Disease

Journal of Ophthalmology
Yuan QiuRongmei Peng

Abstract

This study aims at improving the understanding of the subjective symptoms and signs of two different clinical categories of ocular graft-versus-host disease. After reviewing and screening 193 posthematopoietic stem cell transplantation (HSCT) patients of Peking University Third Hospital, we enrolled 148 (21 acute ocular GVHD, 127 chronic ocular GVHD). Patients' subjective symptoms, ocular parameters, and typical ocular signs were collected and evaluated at the same visit. Classic acute ocular GVHD patients had variable levels of conjunctival involvement but few had keratopathy; increased mucus secretion (21 of 21, 100.0%), red eye (19 of 21, 90.5%), and lacrimation (11 of 21, 52.4%) were the characteristic symptoms. The classic chronic ocular group had severe eye dryness and further corneal lesions, including filamentary keratitis, corneal ulcer, and corneal vascularization. Eye dryness (115 of 127, 90.6%), increased fibrous secretion (53 of 127, 41.7%), photophobia (50 of 127, 39.4%), and alacrimia (45 of 127, 35.4%) were the most common symptoms. Although 44.1% (56 of 127) of these patients had a history of acute ocular GVHD episodes, most were overlooked, so they did not receive stepwise evaluation and treatment. Management ...Continue Reading

References

Sep 1, 1989·Archives of Ophthalmology·D A JabsR Saral
Sep 30, 1999·The British Journal of Ophthalmology·Y OgawaK Tsubota
Mar 14, 2009·Lancet·James L M FerraraErnst Holler
Apr 2, 2013·Survey of Ophthalmology·Hasanain ShikariReza Dana
Dec 23, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Madan H JagasiaMary E D Flowers
Feb 7, 2015·Investigative Ophthalmology & Visual Science·Samantha HerretesVictor L Perez
Jun 3, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yi-Chen SunMadan Jagasia
Jul 15, 2015·Clinical Ophthalmology·Xihui Lin, Harrison Dwight Cavanagh
Jul 28, 2015·Eye & Contact Lens·Saranya C BalasubramaniamMuriel M Schornack
Nov 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Nora MirzaSebastian P Haen
Apr 20, 2017·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Saleha Z Munir, James Aylward
Apr 26, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·H WestekemperK-P Steuhl

❮ Previous
Next ❯

Citations

Sep 4, 2020·Translational Vision Science & Technology·Olivia E O'LearyDavid Goldblum
Nov 2, 2019·Investigative Ophthalmology & Visual Science·Kiumars ShamlooAjay Sharma
Sep 17, 2020·Scientific Reports·Seung Pil BangJong Hwa Jun
Feb 8, 2021·Experimental Eye Research·Konduri RanjithSisinthy Shivaji
Apr 17, 2021·Survey of Ophthalmology·Menachem WeissAhmad Kheirkhah
Feb 4, 2019·Joint, Bone, Spine : Revue Du Rhumatisme·Gaëlle ClavelLuca Semerano
Jul 28, 2020·American Journal of Ophthalmology·Shruti SinhaReza Dana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.