MANIFESTATIONS OF GLUCAGONOMA SYNDROME

AACE Clinical Case Reports
Mauricio AlvarezLuis Zarate

Abstract

Glucagonoma is a rare neuroendocrine tumor of the pancreas. We present the case of a young female patient who presented with the major clinical manifestations of glucagonoma syndrome. The major clinical manifestations of glucagonoma syndrome are described in a 44-year-old, female patient. Beyond glucagonoma, the patient also displayed deep venous thrombosis, depression, diabetes, and necrolytic migratory erythema. We discuss the difficulty of treatment of patients with glucagonoma due to the low prevalence of the disorder, scarcity of medical evidence, lateness of diagnosis with liver metastases in most cases, and poor response to chemotherapy with high rates of relapse after surgery. In this case, pancreatectomy and hepatic lobectomy followed by somatostatin analogue therapy was the chosen treatment strategy. The clinical findings were pancreatic and hepatic masses, proximal deep venous thrombosis, depression, diabetes, and necrolytic migratory erythema. The patient also had elevated levels of glucagon. Pancreatectomy and right hepatic lobectomy were performed and confirmed the glucagonoma. Our case adds new knowledge about glucagonoma which is important due to the low incidence of the disease and the particular characteristic...Continue Reading

References

Nov 13, 2004·European Journal of Endocrinology·Andre P van BeekMarijke R Canninga-van Dijk
Feb 11, 2011·The New England Journal of Medicine·James C YaoUNKNOWN RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group
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Dec 2, 2015·Oncology Letters·Jishu WeiY I Miao
Jul 17, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A M John, R A Schwartz
Jul 28, 2016·Endocrine-related Cancer·Georgios K DimitriadisAshley Grossman
Sep 14, 2016·Biomédica : revista del Instituto Nacional de Salud·Gerzaín RodríguezSergio Cáceres
Jan 12, 2017·The New England Journal of Medicine·Jonathan StrosbergUNKNOWN NETTER-1 Trial Investigators
Dec 20, 2018·The Journal of Clinical Endocrinology and Metabolism·Wouter T ZandeeWouter W de Herder

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