Manipulating Cellular Factors to Combat Viruses: A Case Study From the Plant Eukaryotic Translation Initiation Factors eIF4

Frontiers in Microbiology
Corinne Schmitt-Keichinger

Abstract

Genes conferring resistance to plant viruses fall in two categories; the dominant genes that mostly code for proteins with a nucleotide binding site and leucine rich repeats (NBS-LRR), and that directly or indirectly, recognize viral avirulence factors (Avr), and the recessive genes. The latter provide a so-called recessive resistance. They represent roughly half of the known resistance genes and are alleles of genes that play an important role in the virus life cycle. Conversely, all cellular genes critical for the viral infection virtually represent recessive resistance genes. Based on the well-documented case of recessive resistance mediated by eukaryotic translation initiation factors of the 4E/4G family, this review is intended to summarize the possible approaches to control viruses via their host interactors. Classically, resistant crops have been developed through introgression of natural variants of the susceptibility factor from compatible relatives or by random mutagenesis and screening. Transgenic methods have also been applied to engineer improved crops by overexpressing the translation factor either in its natural form or after directed mutagenesis. More recently, innovative approaches like silencing or genome edit...Continue Reading

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Citations

Jan 8, 2020·BMC Genomics·Pablo A Gutierrez SanchezAurélie M Rakotondrafara
Jan 13, 2021·Current Opinion in Plant Biology·Xueru LiuXin Li
Feb 9, 2021·Virus Genes·Kelvin Josemar M L TeixeiraJosé Evando A Beserra
Jun 22, 2021·Current Opinion in Biotechnology·Hernan Garcia-RuizGuido Van den Ackerveken
Nov 11, 2021·The FEBS Journal·Mary Christie, Cátia Igreja

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Methods Mentioned

BETA
ubiquitination
nucleotide exchange
ELISA
PCR
transgenic
X-ray
gene modifications
two hybrid

Software Mentioned

EcoTILLING
TILLING

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