Manipulating exciton dynamics of thermally activated delayed fluorescence materials for tuning two-photon nanotheranostics.

Chemical Science
Ya-Fang XiaoChun-Sing Lee

Abstract

Rational manipulation of energy utilization from excited-state radiation of theranostic agents with a donor-acceptor structure is relatively unexplored. Herein, we present an effective strategy to tune the exciton dynamics of radiative excited state decay for augmenting two-photon nanotheranostics. As a proof of concept, two thermally activated delayed fluorescence (TADF) molecules with different electron-donating segments are engineered, which possess donor-acceptor structures and strong emissions in the deep-red region with aggregation-induced emission characteristics. Molecular simulations demonstrate that change of the electron-donating sections could effectively regulate the singlet-triplet energy gap and oscillator strength, which promises efficient energy flow. A two-photon laser with great permeability is used to excite TADF NPs to perform as theranostic agents with singlet oxygen generation and fluorescence imaging. These unique performances enable the proposed TADF emitters to exhibit tailored balances between two-photon singlet oxygen generation and fluorescence emission. This result demonstrates that TADF emitters can be rationally designed as superior candidates for nanotheranostic agents by the custom controlling ...Continue Reading

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Citations

Aug 29, 2020·Chemical Communications : Chem Comm·Van-Nghia NguyenJuyoung Yoon
Oct 12, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiangdong XueYuanpei Li
Jan 15, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Xiaozhen LiChun-Sing Lee
Feb 25, 2021·Research : a Science Partner Journal·Ye TaoWei Huang
Mar 20, 2021·Advanced Healthcare Materials·Ka-Wai LeeChun-Sing Lee
Aug 28, 2020·ACS Applied Materials & Interfaces·Alexander M PolgarZachary M Hudson
Sep 28, 2021·Chemical Communications : Chem Comm·Alexander M Polgar, Zachary M Hudson
Nov 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Weihua ZhuangYunbing Wang

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Methods Mentioned

BETA
fluorescence imaging
nuclear magnetic resonance
nanoprecipitation
Fluorescence

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