Manipulating the dynamics of mechanochemical ternary cocrystal formation

Chemical Communications : Chem Comm
Hannes KullaF Emmerling

Abstract

The mechanism of ternary cocrystal formation, and the potential role of intermediate binary phases, has been debated for some time. We report here the first in situ real-time monitoring of two prototypic ternary cocrystals. Our results suggest that the question is more complicated than previously considered. The mechanism of mechanochemical ternary cocrystal formation depends on the milling conditions, here the milling frequency and addition of liquid. Binary phases can form under certain conditions, but do not act as intermediates in the formation of the ternary cocrystals. Rather, binary phases are competitive with the ternary phase, and their formation appears to compete with that of the ternary components. The presence of binary phases leads to an increase in the overall reaction time. The results reported here offer the first insights into the true complexities of mechanochemical multi-component synthesis of higher order multi-component crystals and demonstrate a new understanding of the influence of milling condition for the study of mechanisms and kinetics.

References

Dec 3, 2003·Journal of the American Chemical Society·Eugene Y CheungReiko Kuroda
Jun 2, 2005·Chemical Communications : Chem Comm·Christer B AakeröyJoaquin F Urbina
Jul 25, 2013·Chemical Communications : Chem Comm·Srinu Tothadi, Gautam R Desiraju
Sep 12, 2015·Chemical Communications : Chem Comm·Geetha Bolla, Ashwini Nangia
Nov 14, 2017·Analytical Chemistry·Voraksmy BanNicola Casati
Apr 2, 2018·Angewandte Chemie·Hannes KullaFranziska Emmerling
Apr 6, 2018·Chemical Communications : Chem Comm·Adam A L MichalchukColin R Pulham

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Citations

Jun 23, 2020·Chemistry : a European Journal·Marek PotrzebowskiSlawomir Kazmierski
Apr 21, 2021·Chemical Communications : Chem Comm·Celymar Ortiz-de León, Leonard R MacGillivray
Jun 3, 2021·Pharmaceutics·Mizraín Solares-BrionesJuan M Germán-Acacio

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