Manipulation and capture of Aβ amyloid fibrils and monomers by DC insulator gradient dielectrophoresis (DC-iGDEP).

The Analyst
Sarah J R StatonMark A Hayes

Abstract

Here we report a novel method for the manipulation and concentration of Aβ amyloid fibrils, implicated in Alzheimer's disease, using DC insulating gradient dielectrophoresis (DC-iGDEP). Fibril enrichment was found to be ∼400%. Simulations suggest that capture of the full range of amyloid protein aggregates is possible with optimized device design.

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Citations

Nov 10, 2013·Analytical and Bioanalytical Chemistry·Paul V JonesMark A Hayes
Jun 4, 2014·Analytical Chemistry·Asuka NakanoAlexandra Ros
Feb 13, 2013·Electrophoresis·Asuka Nakano, Alexandra Ros
Mar 18, 2015·Electrophoresis·Paul V Jones, Mark A Hayes
Feb 24, 2015·Bioanalysis·Fernanda Camacho-Alanis, Alexandra Ros
Apr 11, 2017·The Analyst·Claire V Crowther, Mark A Hayes
Aug 17, 2018·Electrophoresis·Blanca H Lapizco-Encinas
Nov 14, 2019·The Analyst·Claire V CrowtherGillian H Gile
Mar 18, 2019·Analytical and Bioanalytical Chemistry·Shannon Huey Hilton, Mark A Hayes
Jul 26, 2019·International Journal of Molecular Sciences·Salman Ali Al-AhdalSharath Sriram
May 28, 2020·Micromachines·Ralph Hölzel, Ronald Pethig
Apr 22, 2020·Analytical and Bioanalytical Chemistry·Mark A Hayes
Jul 25, 2021·Electrophoresis·Morteza M WaskasiMatthias Heyden

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