Manipulation and detection of single nanoparticles and biomolecules by a photonic nanojet

Light, Science & Applications
Yu-Chao LiBao-Jun Li

Abstract

Optical methods to manipulate and detect nanoscale objects are highly desired in both nanomaterials and molecular biology fields. Optical tweezers have been used to manipulate objects that range in size from a few hundred nanometres to several micrometres. The emergence of near-field methods that overcome the diffraction limit has enabled the manipulation of objects below 100 nm. A highly free manipulation with signal-enhanced real-time detection, however, remains a challenge for single sub-100-nm nanoparticles or biomolecules. Here we show an approach that uses a photonic nanojet to perform the manipulation and detection of single sub-100-nm objects. With the photonic nanojet generated by a dielectric microlens bound to an optical fibre probe, three-dimensional manipulations were achieved for a single 85-nm fluorescent polystyrene nanoparticle as well as for a plasmid DNA molecule. Backscattering and fluorescent signals were detected with the enhancement factors up to ∼103 and ∼30, respectively. The demonstrated approach provides a potentially powerful tool for nanostructure assembly, biosensing and single-biomolecule studies.

References

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Citations

Feb 3, 2018·Scientific Reports·Angeleene S AngAlexander S Shalin
Jul 28, 2020·Advanced Materials·Hongbao XinBaojun Li
Jul 17, 2018·Nanoscale·Guoqiang GuJunle Qu
Nov 22, 2018·Applied Optics·Baifu ZhangJianping Ding
May 16, 2019·Optics Letters·Robin PierronSylvain Lecler
Oct 28, 2019·Light, Science & Applications·Yuchao LiBaojun Li
Nov 27, 2020·Frontiers in Chemistry·Elisa Ortiz-RiveroPatricia Haro-González
Mar 19, 2021·ACS Nano·Shaofeng LiuHong-Bo Sun
Oct 15, 2020·Analytical Methods : Advancing Methods and Applications·Ji Yoon Lim, Soo Suk Lee
May 14, 2021·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Zheng Jun LiQing Chao Shang
Aug 28, 2021·Micromachines·Dasheng LuPatricia Haro-González
Sep 2, 2021·Optics Letters·Mohammad Hossein KhosraviFaegheh Hajizadeh
Dec 8, 2021·Light, Science & Applications·Xixi ChenBaojun Li

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Methods Mentioned

BETA
optical tweezers
plasmonic tweezer
Raman scattering
super-resolution optical microscopy
biosensing

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