Manipulation of host cell death pathways during microbial infections

Cell Host & Microbe
Mohamed Lamkanfi, Vishva M Dixit

Abstract

Viral and microbial infections often elicit programmed cell death as part of the host defense system or as a component of the survival strategy of the pathogen. It is thus not surprising that pathogens have evolved an array of toxins and virulence factors to modulate host cell death pathways. Apoptosis, necrosis, and pyroptosis constitute the three major cell death modes for elimination of infected cells. Herein, we discuss the signaling pathways underlying the principal host cell death mechanisms and provide an overview of the strategies employed by viral and microbial pathogens to manipulate these cell death processes.

References

Jan 1, 1994·Annual Review of Immunology·P Matzinger
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·D M MonackS Falkow
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·J L MacenR C Bleackley
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BertinJ I Cohen
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·D M MonackS Falkow
Nov 26, 1998·The Journal of Biological Chemistry·H HilbiA Zychlinsky
Feb 17, 1999·Genes & Development·Q L Deveraux, J C Reed
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·D HershA Zychlinsky
Apr 3, 1999·Annals of Internal Medicine·S E StrausW Strober
Nov 5, 1999·Annual Review of Microbiology·Y Weinrauch, A Zychlinsky
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·C Haslett
Aug 31, 2000·Annual Review of Biochemistry·A StrasserV M Dixit
Dec 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y ShiK L Rock
Apr 21, 2001·Cell Death and Differentiation·N Selliah, T H Finkel
Jun 8, 2001·The Journal of Biological Chemistry·J L PoyetE S Alnemri
Apr 16, 2002·Infection and Immunity·Nicola L JonesPhilip M Sherman
Apr 20, 2002·Cell Death and Differentiation·M LamkanfiP Vandenabeele
May 23, 2002·Biochimie·Kelvin CainGerald M Cohen
Jul 12, 2002·Nature·Paola ScaffidiMarco E Bianchi
Dec 4, 2002·Nature Reviews. Immunology·John SavillChris Haslett
Mar 7, 2003·Molecular Cell·Kelly M BoatrightGuy S Salvesen
Mar 26, 2003·Cell Death and Differentiation·M E Peter, P H Krammer
Mar 26, 2003·Cell Death and Differentiation·U FischerK Schulze-Osthoff
Oct 9, 2003·The Journal of Biological Chemistry·Francis Ka-Ming ChanMichael J Lenardo
Apr 13, 2004·Oncogene·Xavier SaelensPeter Vandenabeele
Jun 11, 2004·Nature·Sanjeev MariathasanVishva M Dixit
Jul 24, 2004·EMBO Reports·Patrizia Rovere-QueriniAngelo A Manfredi
Jan 15, 2005·The Journal of Clinical Investigation·Helen M MarriottDavid H Dockrell
Oct 19, 2005·The Journal of Experimental Medicine·Sanjeev MariathasanDenise M Monack
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
Jan 18, 2006·Cell Death and Differentiation·T Kawai, S Akira
Jan 24, 2006·Nature Genetics·Eric D Boyden, William F Dietrich
Feb 14, 2006·Science·Saquib A LakhaniRichard A Flavell

❮ Previous
Next ❯

Citations

May 21, 2013·Molecular Neurobiology·Meng-Shan TanLan Tan
Apr 24, 2013·Trends in Immunology·Santiago Zelenay, Caetano Reis e Sousa
Nov 15, 2011·Cell Death and Differentiation·N VanlangenakkerP Vandenabeele
Feb 26, 2011·Nature Reviews. Immunology·Mohamed Lamkanfi
Dec 24, 2011·Nature Reviews. Immunology·Edward S MocarskiWilliam J Kaiser
Apr 13, 2011·Infection and Immunity·Jana N RadinTimothy L Cover
Jun 14, 2013·Journal of Virology·Alexsia L Richards, William T Jackson
Feb 22, 2012·Journal of Virology·Saskia C Stein, Erik Falck-Pedersen
May 16, 2013·MBio·Angela K Berger, Pranav Danthi
Oct 8, 2013·PloS One·Yo Han JangBaik Lin Seong
Mar 8, 2013·PLoS Pathogens·Daniela S SilvaNuno M S dos Santos
Apr 5, 2013·PLoS Pathogens·Shawon GuptaJonas Klingström
Sep 20, 2011·Viruses·Judith OlejnikElke Mühlberger
Sep 3, 2013·Antioxidants & Redox Signaling·Claudia N Paiva, Marcelo T Bozza
Dec 21, 2013·Nature·Gilad DoitshWarner C Greene
Feb 12, 2014·Human Gene Therapy·Rodinde HendrickxUrs F Greber
Feb 26, 2014·Trends in Microbiology·Haripriya Sridharan, Jason W Upton
May 3, 2014·Cell Death and Differentiation·S C Chang, J L Ding
May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Dan WengEgil Lien
Jun 24, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Rafael Fernandez-BotranJose Bordon
Oct 15, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jiujiu YuTiffany Horng
Oct 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xing WangSudan He
Sep 15, 2012·Annual Review of Cell and Developmental Biology·Mohamed Lamkanfi, Vishva M Dixit
Sep 6, 2014·Expert Review of Anti-infective Therapy·Nadia T Sebastian, Kathleen L Collins
Nov 30, 2011·The Journal of Cell Biology·Hiroshi AshidaChihiro Sasakawa
May 20, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jing-Wen Shih, Yan-Hwa Wu Lee
Jul 24, 2013·Expert Review of Anticancer Therapy·Xinfang YuYa Cao
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kanna NagamatsuScott J Hultgren
Jul 23, 2015·Chemistry and Physics of Lipids·Young Ah KimRobert Bittman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Lymphoproliferative Syndrome

Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Discover the latest research on ALPS here.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.

Anthrax Vaccines (ASM)

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Related Papers

Cell Death and Differentiation
K Labbé, Maya Saleh
Immunological Reviews
Edward A MiaoAlan Aderem
Microbes and Infection
Linde DuprezPeter Vandenabeele
Nature Reviews. Microbiology
Tessa BergsbakenBrad T Cookson
© 2021 Meta ULC. All rights reserved