Manipulation of metabolic pathways controlled by signaling molecules, inducers of antibiotic production, for genome mining in Streptomyces spp

Antonie van Leeuwenhoek
Kenji Arakawa

Abstract

Streptomyces is well characterized by an ability to produce a wide variety of secondary metabolites including antibiotics, whose expression is strictly controlled by small diffusible signaling molecules at nano-molar concentrations. The signaling molecules identified to date are classified into three skeletons; γ-butyrolactones, furans, and γ-butenolides. Accumulated data suggest the structural diversity of the signaling molecules in Streptomyces species and their potential in activating cryptic secondary metabolite biosynthetic pathways. Several genome mining approaches to activate silent biosynthetic gene clusters have been reported for natural product discovery. This review updates recent examples on genetic manipulation including blockage of metabolic pathways together with inactivation of transcriptional repressor genes.

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Citations

Dec 31, 2018·Applied Microbiology and Biotechnology·Oluwaseyi Samuel Olanrewaju, Olubukola Oluranti Babalola
Nov 27, 2018·Journal of Industrial Microbiology & Biotechnology·Linquan BaiEung-Soo Kim
Jan 11, 2019·Applied Microbiology and Biotechnology·Carlos Barreiro, Miriam Martínez-Castro
May 31, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Mohsen GozariRamin Karimzadeh
Mar 15, 2020·MicrobiologyOpen·Coral García-GutiérrezFelipe Lombó
Feb 3, 2021·Microbiological Research·Polpass Arul JoseBhavanath Jha
Nov 19, 2019·Current Opinion in Microbiology·Olga Genilloud

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Methods Mentioned

BETA
ethyl
Genome sequencing

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