Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease

Neurobiology of Disease
Carola I RadulescuMahmoud A Pouladi

Abstract

Structural and molecular myelination deficits represent early pathological features of Huntington disease (HD). Recent evidence from germ-free (GF) animals suggests a role for microbiota-gut-brain bidirectional communication in the regulation of myelination. In this study, we aimed to investigate the impact of microbiota on myelin plasticity and oligodendroglial population dynamics in the mixed-sex BACHD mouse model of HD. Ultrastructural analysis of myelin in the corpus callosum revealed alterations of myelin thickness in BACHD GF compared to specific-pathogen free (SPF) mice, whereas no differences were observed between wild-type (WT) groups. In contrast, myelin compaction was altered in all groups when compared to WT SPF animals. Levels of myelin-related proteins were generally reduced, and the number of mature oligodendrocytes was decreased in the prefrontal cortex under GF compared to SPF conditions, regardless of genotype. Minor differences in commensal bacteria at the family and genera levels were found in the gut microbiota of BACHD and WT animals housed in standard living conditions. Our findings indicate complex effects of a germ-free status on myelin-related characteristics, and highlight the adaptive properties of m...Continue Reading

Citations

Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
Mar 18, 2020·Glia·Daniel Erny, Marco Prinz
Apr 14, 2020·Current Topics in Medicinal Chemistry·Sreyashi ChandraPrem P Tripathi
Apr 3, 2019·Molecular Neurobiology·Roy Tang Yi TeoMahmoud A Pouladi
Sep 27, 2019·Current Opinion in Pharmacology·Giorgia TosoniRochellys Diaz Heijtz
Nov 27, 2020·Curēus·Likhita ShaikSahil Khanna
Jun 9, 2020·Trends in Molecular Medicine·Ayoze Gonzalez-Santana, Rochellys Diaz Heijtz
Aug 14, 2020·Cell Host & Microbe·P FangE Y Hsiao
May 27, 2021·Journal of Agricultural and Food Chemistry·Hanieh NargehHamidreza Pazoki-Toroudi
Aug 10, 2021·Journal of Huntington's Disease·Costanza Ferrari BardileMahmoud A Pouladi
Aug 28, 2021·Acta Neuropathologica·Sanaz GaberyÅsa Petersén

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.