Manipulation of NKG2D ligands by cytomegaloviruses: impact on innate and adaptive immune response.

Frontiers in Immunology
Irena SlavuljicaStipan Jonjić

Abstract

NKG2D is a potent activating receptor expressed on NK cells, NKT cells, γδ T cells, and CD8 T cells. NKG2D recognizes cell surface molecules structurally related to MHC class I proteins induced by infection or other type of cellular stress. The engagement of NKG2D leads to NK cell cytotoxicity and cytokine secretion or to a co-stimulation of CD8 T cells. Both human and mouse cytomegalovirus (CMV) have evolved numerous mechanisms to evade NKG2D-mediated immune response. This review describes the mechanisms used by CMV to inhibit NKG2D ligand expression and the recent advances in exploiting the NKG2D recognition pathway for mounting efficient and long-lasting immune response.

Citations

Jul 25, 2015·Current Opinion in Virology·Berislav LisnićStipan Jonjić
Feb 6, 2015·Frontiers in Immunology·Lionel CouziJulie Déchanet-Merville
Sep 1, 2016·PLoS Pathogens·Elizabeth R SturgillKlaus Früh
Jan 15, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maja LenartićBojan Polić
Oct 20, 2019·Vaccines·Mario Alberto Ynga-DurandLuka Cicin-Sain
Mar 21, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mathieu Bléry, Eric Vivier

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