Manipulation of starch bioaccessibility in wheat endosperm to regulate starch digestion, postprandial glycemia, insulinemia, and gut hormone responses: a randomized controlled trial in healthy ileostomy participants

The American Journal of Clinical Nutrition
Cathrina H EdwardsP R Ellis

Abstract

Cereal crops, particularly wheat, are a major dietary source of starch, and the bioaccessibility of starch has implications for postprandial glycemia. The structure and properties of plant foods have been identified as critical factors in influencing nutrient bioaccessibility; however, the physical and biochemical disassembly of cereal food during digestion has not been widely studied. The aims of this study were to compare the effects of 2 porridge meals prepared from wheat endosperm with different degrees of starch bioaccessibility on postprandial metabolism (e.g., glycemia) and to gain insight into the structural and biochemical breakdown of the test meals during gastroileal transit. A randomized crossover trial in 9 healthy ileostomy participants was designed to compare the effects of 55 g starch, provided as coarse (2-mm particles) or smooth (<0.2-mm particles) wheat porridge, on postprandial changes in blood glucose, insulin, C-peptide, lipids, and gut hormones and on the resistant starch (RS) content of ileal effluent. Undigested food in the ileal output was examined microscopically to identify cell walls and encapsulated starch. Blood glucose, insulin, C-peptide, and glucose-dependent insulinotropic polypeptide concentr...Continue Reading

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May 19, 2016·Food & Function·P J Lillford
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Methods Mentioned

BETA
ELISA

Clinical Trials Mentioned

ISRCTN40517475

Software Mentioned

Power
AxioVision
NetWisp
SigmaPlot
Tinuviel
Systat
SPSS Statistics

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