Mannan Derivatives Instruct Dendritic Cells to Induce Th1/Th2 Cells Polarization via Differential Mitogen-Activated Protein Kinase Activation

Scandinavian Journal of Immunology
Chunyu TongWenyu Han

Abstract

Mannan derived from fungal cell walls have potential uses as immunomodulating agents and vaccine adjuvants. Immunization with antigen conjugated to oxidized mannan (OM) or reduced mannan (RM) have induced differential immune responses in mice. Yet, the adjuvant effect and differences in molecular profiles of OM and RM on APCs is unresolved. Here, we investigated the response of mouse bone marrow-derived DCs to OM and RM. OM and RM stimulated DCs to produce differential Th1/Th2-inducing cytokines in vitro. OM and RM-activated DCs stimulated allogeneic T-cell Th1 and Th2 polarization reaction. OM instruct DCs to stimulate Th1 responses via IL-12p70 production, which depends on the phosphorylation of p38, RM barely induce IL-12p70, but IL-10 and IL-4, and magnitude of ERK phosphorylation, which results in a Th2 bias. These findings indicate that OM and RM were potent adjuvant capable of directly initiating DC activation Th1 and Th2 polarization respectively.

References

Jun 4, 2005·Advances in Experimental Medicine and Biology·Chandrashekhar Pasare, Ruslan Medzhitov
Jul 11, 2006·Immunology·Kuo-Ching ShengVasso Apostolopoulos
May 4, 2007·The Journal of Clinical Investigation·Ilona Gutcher, Burkhard Becher
Dec 15, 2007·Nature Reviews. Microbiology·Mihai G NeteaNeil A R Gow
Apr 16, 2009·Clinical Microbiology Reviews·Trine H Mogensen
Apr 22, 2009·Cell Host & Microbe·Frank L van de VeerdonkMihai G Netea
Dec 17, 2009·Cell Research·Jinfang Zhu, William E Paul
Feb 6, 2010·Science·Frederic GeissmannKlaus Ley
Apr 15, 2011·European Journal of Immunology·Anne DudeckMarcus Maurer
Jul 19, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bernadette FerraroDavid B Weiner
Oct 5, 2011·Journal of Mammary Gland Biology and Neoplasia·Mini Bharathan, Isis K Mullarky
Jan 10, 2012·Annual Review of Immunology·David Sancho, Caetano Reis e Sousa
Jan 12, 2012·Cellular Microbiology·S HontelezG J Adema
Feb 22, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mi Young JungTae Sung Kim
May 26, 2012·Nature Reviews. Immunology·Anita S Chong, Maria-Luisa Alegre
Sep 11, 2012·Fish & Shellfish Immunology·Xian-Wei Wang, Jin-Xing Wang
Mar 19, 2013·Expert Review of Vaccines·Pawel KalinskiJulie Urban
Jul 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hanna LeeShizuo Akira
Aug 24, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Yicheng MaoNatarajan Muthusamy
Sep 3, 2013·The Journal of Surgical Research·Bocui SongXuming Deng
Apr 8, 2014·Trends in Immunology·Ellen V Rothenberg
May 27, 2014·International Immunopharmacology·Jong-Jin KimSung-Tae Yee
Aug 15, 2014·Nanotechnology·Azita HaddadiAfsaneh Lavasanifar
Nov 26, 2014·Seminars in Immunopathology·Anthony PlatoGordon D Brown

❮ Previous
Next ❯

Citations

Sep 30, 2008·BMC Pulmonary Medicine·Carl VaelKristine N Desager
Apr 28, 2010·PLoS Neglected Tropical Diseases·Bart EvertsMaria Yazdanbakhsh
Jun 21, 2016·Expert Opinion on Drug Delivery·Sandra ScheiblhoferRichard Weiss
Nov 12, 2010·Tuberculosis·David A Hokey, Amit Misra
Oct 18, 2005·Advances in Immunology·Francesca GranucciPaola Ricciardi-Castagnoli
Jun 23, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hesham H SalmanJuan M Irache
May 6, 2006·The Journal of Allergy and Clinical Immunology·Anthony A Horner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.