Mannitol therapy in perinatal hypoxic-ischemic brain damage in rats

Stroke; a Journal of Cerebral Circulation
D J MujsceR C Vannucci

Abstract

To study the efficacy of mannitol in reducing cerebral edema and improving the ultimate neuropathologic outcome in perinatal cerebral hypoxia-ischemia, 67 7-day postnatal rats were subjected to unilateral common carotid artery ligation followed by exposure to 8% oxygen at 37 degrees C for 3 hours. Twenty-seven rat pups received a subcutaneous injection of 0.1 ml mannitol in a dosage of 4 mg/kg body wt immediately following cerebral hypoxia-ischemia and every 12 hours thereafter for a total of four doses. Control animals received either no therapy (n = 16) or an equivalent volume of normal saline (n = 24). Mannitol injections in six rat pups not subjected to hypoxia-ischemia produced no mortality but significantly increased serum osmolality from 287 to 361 mos/l (p less than 0.01). Preliminary studies indicated that substantial mortality occurred when greater doses of mannitol were administered to rats. After 48 hours of recovery from hypoxia-ischemia, the animals were killed and their brains were examined for either tissue water content (33 rat pups) or the presence of neuropathologic alterations (34 rat pups). Mannitol significantly reduced (p less than 0.001) brain water content, as a reflection of cerebral edema, in both the...Continue Reading

References

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Citations

Jan 1, 1991·Acta Neuropathologica·J TowfighiR C Vannucci
Dec 8, 2010·Neurochemical Research·Diana Carolina FerrariJose Regino Perez-Polo
Jul 17, 1998·Annals of Medicine·S Vanhatalo, S Soinila
Feb 10, 2010·Journal of Neuroscience Research·Diana Carolina FerrariJ Regino Perez-Polo
Aug 3, 2001·Seminars in Neonatology : SN·Z S Vexler, D M Ferriero
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R C VannucciS J Vannucci

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