Mannose-binding lectin and the prognosis of fulminant hepatic failure caused by HBV infection

Liver
Yukiya HakozakiN Wakamiya

Abstract

The mannose-binding lectin (MBL) gene was reported to play an important role in determining the clinical outcome of persistent hepatitis B virus (HBV) infection. We investigated serum MBL concentrations and MBL gene mutations to determine whether they were related to the prognosis of patients with fulminant hepatic failure (FHF) caused by HBV infection. We investigated serum MBL concentrations and MBL gene mutations in 43 HBV-infected Japanese patients with FHF and 260 HBsAg-negative healthy controls. Serum MBL concentrations were measured by an enzyme-linked immunosorbent assay, and mutations in the MBL gene were analysed by nested PCR and direct DNA sequencing. Only a mutation in codon 54 of the MBL gene was found. The frequency of this mutation in nonsurvivors (40%, 8/20) was higher than in survivors (13%, 3/23), and the difference was slightly significant (p = 0.043). The H allele frequency in survivors (70.5%, 31/44) was higher than in nonsurvivors (39.5%, 15/38) (p = 0.0048). Because of these factors the mean serum MBL concentration in survivors, 1.61 ,micro/ml (range 0.3-3.86), was significantly higher than in nonsurvivors, 0.79 microg/ml (range 0.04-1.51) (p < 0.0001). The likelihood ratio for nonsurvival was 0 for over...Continue Reading

References

Jun 29, 1991·Lancet·M SumiyaJ A Summerfield
Jun 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H TsubouchiY Muto
Sep 15, 1989·The Biochemical Journal·M E TaylorJ A Summerfield
Mar 1, 1988·American Journal of Clinical Pathology·J A RowellI H Bunce
Jan 1, 1987·Journal of General Internal Medicine·B J Goldstein, A I Mushlin
Sep 1, 1970·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C BodeG Strohmeyer
Jan 28, 1984·British Medical Journal·C BrechotJ P Benhamou
May 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J ScottoC Brechot
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S Lok
Feb 1, 1995·Journal of Gastroenterology·M YoshibaR Fujita
Apr 20, 1995·The New England Journal of Medicine·M R ThurszA V Hill
Jul 1, 1993·The Biochemical Journal·R MalhotraR B Sim
Feb 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T Tomiya, K Fujiwara
Mar 1, 1996·British Journal of Sports Medicine·B Ytterstad
Aug 1, 1997·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J AittoniemiE Soppi
Aug 28, 1998·Bioscience, Biotechnology, and Biochemistry·S EdaN Wakamiya
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M F YuenC L Lai
Jun 10, 2000·Journal of Gastroenterology and Hepatology·S K AcharyaS D Gupta
Nov 4, 2000·Scandinavian Journal of Gastroenterology·K SasakiT Koike
Apr 17, 2001·Annals of the Rheumatic Diseases·Z Y WangS Kumagai
Jul 5, 2007·Journal of Lipid Research·Barbara P AtshavesFriedhelm Schroeder

❮ Previous
Next ❯

Citations

Jul 2, 2008·Journal of Clinical Immunology·Eirini KoutsounakiEmmanouil Galanakis
Jul 20, 2002·Current Opinion in Pharmacology·Stephen Chanock, James G Taylor
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Damon P Eisen, Robyn M Minchinton
Oct 21, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kazue Takahashi, R Alan B Ezekowitz
Sep 7, 2011·Journal of Biochemistry·Takayuki YoshizakiNobutaka Wakamiya
Jan 29, 2008·Journal of Viral Hepatitis·L SegatS Crovella
Jun 15, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·V BallegaardL Munthe-Fog
Apr 18, 2012·Alimentary Pharmacology & Therapeutics·K A WlodzimirowR A F M Chamuleau
Sep 10, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Tea L LaursenUNKNOWN US Acute Liver Failure Study Group
Dec 13, 2006·Immunology Letters·Kristelle S BrownTimothy P Hickling
Dec 22, 2005·Current Opinion in Immunology·Kazue TakahashiR Alan B Ezekowitz
Oct 23, 2004·Clinical and Experimental Immunology·M GadjevaJ C Jensenius
Jan 21, 2003·The Journal of General Virology·Herman W FavoreelMaurice B Pensaert
May 19, 2004·Clinical and Experimental Immunology·R TakahashiT Sumida
Feb 28, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mineji HayakawaNobutaka Wakamiya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.