Mannose-binding lectin deficiency and predisposition to recurrent infection in adults

Journal of Clinical Pathology
Jenny HoldawayYousuf Karim

Abstract

The effects of mannose-binding lectin (MBL) deficiency are well known in children and in those with a compromised immune system. However, its effects in adults are debateable, with little research having been carried out in the UK regarding infection risk in otherwise healthy adults with an MBL deficiency. Using an ELISA, we investigated the prevalence of MBL deficiency in both healthy adults and those with recurrent infection. The aim was to determine first if there was a disparity in MBL levels between the two groups and second to investigate the effect of severe deficiency. Overall, the difference between the two groups for MBL level was found not to be statistically significant (p=0.203); however, there was a higher prevalence of severe deficiency (MBL<75 ng/mL) in the patients with recurrent infection (p=0.03). It was concluded that there is justified reason for continuing to perform the MBL test in adult patients suffering recurrent infection.

References

Jun 29, 1991·Lancet·M SumiyaJ A Summerfield
Feb 1, 1994·Immunology Today·U HolmskovJ C Jensenius
Jan 13, 2001·Current Opinion in Immunology·M GadjevaJ C Jensenius
Mar 20, 2001·JAMA : the Journal of the American Medical Association·A KochP Garred
May 30, 2002·Nature Reviews. Immunology·Teizo Fujita
Jul 31, 2003·Biochemical Society Transactions·H Valdimarsson
Aug 9, 2003·The New England Journal of Medicine·Kristian Stengaard-PedersenJens C Jensenius
Oct 22, 2003·Molecular Immunology·M W Turner
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Damon P Eisen, Robyn M Minchinton
May 19, 2004·The Journal of Experimental Medicine·Jean-Laurent Casanova, Laurent Abel
May 19, 2004·The Journal of Experimental Medicine·Morten DahlBørge G Nordestgaard
Aug 17, 2006·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Olaf A BodamerWolfgang M Schmidt
Sep 23, 2006·Journal of Clinical Immunology·Kenneth Ahrend PetersenMads Axelsen
Jun 28, 2008·The Journal of Allergy and Clinical Immunology·M Isabel Garcia-LaordenCarlos Rodriguez-Gallego
Nov 22, 2008·Biochemical Society Transactions·Peter Garred
Jan 16, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel L WorthleyCharles G Mullighan
May 26, 2009·The International Journal of Biochemistry & Cell Biology·Helga D MantheyPeter N Monk
Jul 15, 2009·Clinical Microbiology Reviews·Ari J Fried, Francisco A Bonilla
Jun 24, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tobias StrunkDavid Burgner
Jun 1, 2011·Molecular Immunology·Lillemor SkattumLennart Truedsson
Nov 26, 2011·Expert Review of Anti-infective Therapy·Kazue Takahashi
Mar 2, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sabine HeitzenederAndreas Heitger
Jul 27, 2014·The Annals of Otology, Rhinology, and Laryngology·Jeb M JusticeDonald C Lanza

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Citations

Jun 27, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J Lombardo-QuezadaM Navasa
Nov 1, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mario Fernández-RuizOriol Manuel
Mar 29, 2019·Current Opinion in Pulmonary Medicine·Ger T RijkersTiara Dusselier
Aug 29, 2017·Current Stem Cell Reports·Mateusz Adamiak, Mariusz Z Ratajczak
Mar 16, 2018·Frontiers in Psychiatry·Mariusz Z RatajczakJerzy Samochowiec
Aug 5, 2019·Journal of Clinical Immunology·Clara Mistegård JørgensenSteffen Thiel
Aug 21, 2020·Journal of Inflammation·Sofie JacobsonStefan Söderberg
Oct 13, 2020·Frontiers in Pediatrics·Cinzia AuritiVincenzo Maria Di Ciommo

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