Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome

The Journal of Experimental Medicine
Wk Eddie IpR Alan B Ezekowitz

Abstract

Innate immunity is the first-line defense against pathogens and relies on phagocytes, soluble components, and cell-surface and cytosolic pattern recognition receptors. Despite using hard-wired receptors and signaling pathways, the innate immune response demonstrates surprising specificity to different pathogens. We determined how combinatorial use of innate immune defense mechanisms defines the response. We describe a novel cooperation between a soluble component of the innate immune system, the mannose-binding lectin, and Toll-like receptor 2 that both specifies and amplifies the host response to Staphylococcus aureus. Furthermore, we demonstrate that this cooperation occurs within the phagosome, emphasizing the importance of engulfment in providing the appropriate cellular environment to facilitate the synergy between these defense pathways.

References

Jan 1, 1990·American Journal of Respiratory Cell and Molecular Biology·F van IwaardenL M van Golde
Sep 21, 1990·Science·R R SchumannR J Ulevitch
May 1, 1989·The Journal of Experimental Medicine·M KuhlmanR A Ezekowitz
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·C A Janeway
Oct 1, 1987·The Journal of Cell Biology·J A Cooper
Jan 1, 1996·Infection and Immunity·V Y PolotskyK A Joiner
May 21, 1999·Science·J A HoffmannR A Ezekowitz
Jun 8, 1999·The Journal of Experimental Medicine·R ShimazuM Kimoto
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·O TakeuchiS Akira
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·A OzinskyA Aderem
Dec 20, 2000·The Journal of Experimental Medicine·I GhiranA Nicholson-Weller
Mar 20, 2001·JAMA : the Journal of the American Medical Association·A KochP Garred
Jul 12, 2001·Infection and Immunity·I K SantosJ E Epstein
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Feb 28, 2002·Annual Review of Immunology·David M Underhill, Adrian Ozinsky
Sep 20, 2002·The Journal of Biological Chemistry·Kathryn J MooreMason W Freeman
Apr 30, 2003·The Journal of Experimental Medicine·Gordon D BrownSiamon Gordon
Apr 30, 2003·The Journal of Experimental Medicine·Benjamin N GantnerDavid M Underhill
May 19, 2004·The Journal of Experimental Medicine·Lei ShiR Alan B Ezekowitz
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Dec 15, 2004·Microbes and Infection·Katherine A FitzgeraldDouglas T Golenbock
Feb 4, 2005·Nature·Kasper HoebeBruce Beutler
Apr 20, 2005·The Journal of Infectious Diseases·W K Eddie IpYu Lung Lau
Oct 21, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kazue Takahashi, R Alan B Ezekowitz
Nov 22, 2005·Infection and Immunity·Kazue TakahashiR Alan B Ezekowitz
Dec 22, 2005·Current Opinion in Immunology·Kazue TakahashiR Alan B Ezekowitz
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mette Møller-KristensenKazue Takahashi
Apr 1, 2006·Biochemical and Biophysical Research Communications·Michael J PodolskyKazue Takahashi
May 23, 2006·Nature Medicine·Markus Huber-LangPeter A Ward
Nov 18, 2006·Nature Immunology·Jörg H FritzStephen E Girardin
Nov 18, 2006·Nature Immunology·Matthew J RobinsonCaetano Reis e Sousa

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Citations

Sep 24, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Josias Brito FrazãoAntonio Condino-Neto
May 6, 2011·Rheumatology International·Churl Hyun ImYeong Wook Song
Jun 10, 2010·Immunology and Cell Biology·Jason G Cyster
Aug 20, 2010·Nature Immunology·Daniel RicklinJohn D Lambris
Apr 22, 2010·The Journal of Biological Chemistry·Guillaume M CharrièreLynda M Stuart
Jul 20, 2010·Human Molecular Genetics·Jan FreudenbergPeter K Gregersen
Nov 21, 2012·Infection and Immunity·Tanja Petnicki-OcwiejaLinden T Hu
Dec 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Elizabeth A MischThomas R Hawn
Dec 9, 2009·Annual Review of Immunology·Barbara BottazziAlberto Mantovani
Apr 27, 2012·Journal of Biomedicine & Biotechnology·Mykol LarvieKazue Takahashi
May 30, 2009·Molecular Immunology·Andreas KlosJörg Köhl
Aug 29, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ashish Arunkumar SharmaPascal M Lavoie
Mar 31, 2012·Immunobiology·Katja HunoldDaniela N Männel
Feb 22, 2011·Biochemical and Biophysical Research Communications·Hee Jung KangBok Luel Lee
Jan 12, 2010·Current Opinion in Immunology·Anne F McGettrick, Luke A J O'Neill
Oct 21, 2009·Biochimica Et Biophysica Acta·Takeyuki ShimizuYoshio Kuroki
Jun 6, 2009·Seminars in Immunology·Richard I Tapping
Jul 15, 2009·Immunological Reviews·W K Eddie IpLynda M Stuart
Apr 19, 2008·Journal of Cellular and Molecular Medicine·Morten Harboe, Tom Eirik Mollnes
Mar 27, 2013·Annals of the New York Academy of Sciences·Alberto MantovaniCecilia Garlanda
Jul 2, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bert-Jan F de RooijHein W Verspaget
Oct 26, 2012·The FEBS Journal·Hiroshi NakayamaBok Luel Lee
May 15, 2012·Traffic·Jonathan C Kagan, Akiko Iwasaki

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Methods Mentioned

BETA
Protein array
ELISA
flow cytometry
fluorescence microscopy
Immunoprecipitation
lavage
FCS
protein
Antibody Array
Assay

Software Mentioned

Improvision
Excel
CellQuest Pro
Openlab
JMP

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