Mannose-Binding Lectin Gene Polymorphism and Its Association with Susceptibility to Recurrent Vulvovaginal Candidiasis

BioMed Research International
Noha M HammadLaila M Al Kady

Abstract

Recurrent vulvovaginal candidiasis (RVVC) is a common illness influencing childbearing women worldwide. Most women suffering from RVVC develop infection without specified risk factors. Mannose-binding lectin (MBL) is an important component of innate immune defense against Candida infection. Innate immunity gene mutations and polymorphisms have been suggested to play a role in susceptibility to RVVC. This study aimed to investigate the association between MBL 2 gene exon 1 codon 54 polymorphism and susceptibility to RVVC in childbearing women. Whole blood and serum samples were obtained from 59 RVVC cases and 59 controls. MBL serum level was measured by enzyme-linked immune-sorbent assay (ELISA). MBL2 exon 1 codon 54 polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). It was shown that MBL serum level was nonsignificantly different between RVVC cases and controls. The risk of RVVC was 3 times higher in those carrying MBL2 exon 1 codon 54 variant allele (B). It could be concluded that the carrying of MBL2 exon 1 codon 54 variant allele (B) was shown to be a risk factor for RVVC in childbearing women.

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Citations

Jan 25, 2020·Microorganisms·Diletta RosatiMihai G Netea
Jul 1, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Noha M HammadAyman Marei
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Dec 16, 2021·International Journal of Immunopathology and Pharmacology·Shereen A BaioumySara I Taha

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay
electrophoresis
genotyping

Software Mentioned

Statistical Package for the Social Sciences software

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