Mar 3, 2009

Mannose binding lectin gene polymorphism and the severity of chronic periodontitis

Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology
Akito TsutsumiT Sumida

Abstract

Mannose binding lectin (MBL) is a key molecule in first line defense against various microorganisms. Polymorphism of the MBL gene greatly affects serum MBL concentration, and is known to be associated with occurrence of infectious diseases. We aimed to determine whether there is a relationship between occurrence or severity of chronic periodontitis (CP) and polymorphism of the MBL gene. Ninety-eight CP patients and 63 healthy subjects with no periodontitis were typed for the codon 54 polymorphism of the MBL gene by PCR-restriction fragment length polymorphism method. Genotype frequencies of the codon 54 polymorphism were similar between patients and control subjects. When patients were categorized to mild, moderate and severe periodontitis groups, possession of the low serum MBL concentration allele was a risk factor for having severe CP, as assessed by logistic regression analysis. Patients with MBL genotypes that cause lower serum MBL concentration may be at risk of having severe periodontitis. MBL gene typing may become useful to predict the prognosis of CP.

  • References13
  • Citations2

References

  • References13
  • Citations2

Citations

Mentioned in this Paper

Microorganism
Gene Polymorphism
Mannose Binding Lectin
Restriction Fragment Length Polymorphism
Codon Genus
Codon (Nucleotide Sequence)
MBL2 gene
Regression Analysis
Periodontitis
Alleles

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