Mannose-binding lectin gene polymorphism is a modulating factor in repeated respiratory infections

Chest
Kazunori GomiToshihiro Nukiwa

Abstract

To clarify how mannose-binding lectin (MBL) participates in the pulmonary defense system. Multicenter retrospective study. Sixty-two patients with unexplained recurrent respiratory infections, 50 patients with nontuberculous mycobacterial infection, 23 patients with aspergillosis, and 49 patients with diffuse panbronchiolitis (DPB). For controls, 52 blood samples were provided by the Blood Donation Center of the Japanese Red Cross Society. For BAL fluid (BALF) evaluation, there were five patients with acute phase pneumonia and five healthy volunteers. We demonstrated that MBL protein could be directly measured in the BALF from the lungs of patients with pneumonia by means of enzyme-linked immunosorbent assay. Furthermore, we demonstrated that the prevalence of the codon 54 mutation of the MBL gene in 62 patients having repeated respiratory infections was significantly higher compared with healthy control subjects (54.8% vs 32.7%). The prevalence of the MBL mutant genotype among patients with DPB was higher (51.1%) than in the rest of the patients. In contrast, the prevalence of the MBL mutant genotype among patients with nontuberculous mycobacteria or Aspergillus chronic infection was not significantly different from that in co...Continue Reading

References

Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E M AndersD C Jackson
May 1, 1989·The Journal of Experimental Medicine·M KuhlmanR A Ezekowitz
Apr 2, 1998·Current Opinion in Immunology·M MatsushitaT Fujita
Jun 25, 1998·Archives of Virology·M MatsushitaS Mishiro
Aug 3, 2000·The New England Journal of Medicine·R Medzhitov, C Janeway

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Citations

Oct 24, 2007·Journal of Clinical Immunology·Lucas Zimon Giacomini RibeiroDivina Aparecida Oliveira Queiróz
Feb 15, 2008·The New England Journal of Medicine·Joseph P Mizgerd
Nov 30, 2006·Critical Care Medicine·Michelle N GongDavid C Christiani
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mary K DahmerMichael W Quasney
Dec 2, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kenneth J MukamalEric B Rimm
Jan 15, 2010·Annual Review of Public Health·Stavros Garantziotis, David A Schwartz
Mar 27, 2010·Clinical and Molecular Allergy : CMA·Christopher MillerGuha Krishnaswamy
Dec 12, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Richard K AlbertPrescott G Woodruff
Jan 31, 2008·Journal of Clinical Biochemistry and Nutrition·Fang-Yu WangHiroshi Nakano
Mar 28, 2008·Digestive Diseases and Sciences·Fang-Yu WangIchiro Hirata
Jul 5, 2008·Expert Review of Molecular Diagnostics·Rita A Trammell, Linda A Toth
Jan 27, 2016·International Journal of Pediatric Otorhinolaryngology·Ozlem AtanFerda Ozkınay
Oct 31, 2012·Gene·Lyubov E SalnikovaAlexander V Rubanovich
Jun 28, 2008·The Journal of Allergy and Clinical Immunology·M Isabel Garcia-LaordenCarlos Rodriguez-Gallego
Oct 5, 2007·Microbes and Infection·Alex van BelkumWillem van Leeuwen
Oct 3, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Z-D PanaE Roilides
Jun 15, 2007·International Journal of Pediatric Otorhinolaryngology·Guldane KoturogluFerda Ozkinay
Aug 15, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kunio YanagisawaYoshihisa Nojima
Sep 24, 2005·Clinical and Experimental Immunology·J AittoniemiJ Karjalainen
Sep 1, 2005·Pediatric Pulmonology·Matthias Griese, Vitaliy Starosta
Aug 18, 2005·Internal Medicine Journal·D L WorthleyC G Mullighan
Aug 15, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Luregn Jan SchlapbachUrs Frey
Jan 1, 2009·The Clinical Respiratory Journal·David Chalmers KilpatrickAdam Hill
Mar 6, 2007·Clinical and Experimental Immunology·S KaurT Madan
Feb 16, 2006·Scandinavian Journal of Immunology·L Bak-RomaniszynI Płaneta-Małecka
Dec 1, 2005·Scandinavian Journal of Immunology·I DowningD C Kilpatrick
Jan 19, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M de Martino, S Ballotti
Jan 10, 2012·International Journal of Immunogenetics·E HarrisonD W Denning
May 8, 2013·International Journal of Cancer. Journal International Du Cancer·Shun LuAsta Försti
Feb 16, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Lyubov E SalnikovaAlexander V Rubanovich
Dec 17, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M A F QueirozA C R Vallinoto

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