Mannose-binding lectin is involved in multiple organ dysfunction syndrome after cardiac surgery: effects of blood transfusions

Transfusion
Yavuz M BilginA Roos

Abstract

Serum levels of mannose-binding lectin (MBL), a recognition molecule of the lectin pathway of complement, are highly variable, based on genetic variation. After cardiac surgery, extracorporeal circulation and ischemia-reperfusion injury initiate a systemic inflammatory response, which can evolve to multiple organ dysfunction syndrome (MODS). Preoperative transfusions of allogeneic white blood cells (WBCs) contribute to infectious and inflammatory complications. This study investigates the role of MBL in relation to blood transfusions and complications after cardiac surgery. In cardiac surgery patients who participated in a randomized trial comparing leukoreduced with buffy coat-depleted red blood cell (RBC) transfusions, circulating MBL was measured pre- and postoperatively by enzyme-linked immunosorbent assay (ELISA). Data were related to the incidence of complications and to the transfusions the patients received. Patients with high preoperative serum MBL levels (>400 ng/mL) show a significant (52 +/- 12%) decrease of serum MBL postoperatively, whereas patients with low serum MBL levels (< or =400 ng/mL) show a significant increase of serum MBL levels after surgery (140 +/- 106%), which was further enhanced by fresh-frozen pl...Continue Reading

References

Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Dec 1, 1985·Annals of Surgery·W A KnausJ E Zimmerman
Sep 25, 2002·Microbes and Infection·Kazue TakahashiR Alan B Ezekowitz
May 19, 2004·The Journal of Experimental Medicine·Morten DahlBørge G Nordestgaard
Oct 7, 2004·Glycoconjugate Journal·Kazuhide UemuraToshisuke Kawasaki
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melanie L HartGregory L Stahl
May 11, 2005·Scandinavian Journal of Immunology·M Møller-KristensenM Gadjeva
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stefan P BergerMohamed R Daha
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary C WalshGregory L Stahl
Nov 10, 2005·Critical Care : the Official Journal of the Critical Care Forum·Michael SiassiJoachim Schmidt
Nov 18, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M G A NorwoodW J Schwaeble
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming ZhangMichael C Carroll
Aug 7, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anja RoosStefan P Berger

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Citations

Jun 12, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Magdalena Pertyńska MarczewskaJan Wilczyński
Nov 28, 2013·Scientifica·W van Oeveren
Dec 16, 2010·Current Opinion in Organ Transplantation·Stefan P Berger, Mohamed R Daha
Nov 26, 2011·Expert Review of Anti-infective Therapy·Kazue Takahashi
Aug 25, 2010·Human Immunology·Cinzia AuritiFabrizio De Benedetti
Feb 23, 2010·The Annals of Thoracic Surgery·Cornelia HoedemaekersJohannes van der Hoeven
Jan 16, 2013·Clinical & Developmental Immunology·Daniel RittirschMarkus Huber-Lang
May 31, 2014·BioMed Research International·Izabela Pągowska-Klimek, Maciej Cedzyński
Nov 8, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Erik C MadsenAdrienne G Randolph
May 30, 2019·Frontiers in Immunology·Emily R LevyAdrienne G Randolph

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