Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus

Arthritis and Rheumatism
K E SullivanM A Petri

Abstract

To determine whether dysfunctional or deficient mannose-binding protein (MBP) variants are found with increased frequency in black patients with systemic lupus erythematosus (SLE) compared with controls. Allele-specific polymerase chain reaction amplification of 4 different polymorphic sites was performed on samples from 92 black SLE patients and 86 geographically matched black controls. Two structural polymorphisms of MBP, associated with low serum levels of MBP, were found with significantly increased frequency in the SLE patient population compared with controls. In contrast, a promoter haplotype associated with particularly high serum levels of MBP was negatively associated with SLE. Deficiencies of MBP predispose individuals to SLE.

References

Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·L M KunkelJ M Rary
Jun 29, 1991·Lancet·M SumiyaJ A Summerfield
Feb 20, 1992·Nature·C Anderson
Sep 1, 1983·Journal of Biochemistry·N KawasakiI Yamashina
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Sep 1, 1993·The Journal of Clinical Investigation·T WitteR E Schmidt
Jan 1, 1995·Arthritis and Rheumatism·E J DaviesW E Ollier
Dec 1, 1994·QJM : Monthly Journal of the Association of Physicians·J W Paulley
Aug 1, 1994·Clinical and Experimental Immunology·R MalhotraR B Sim
Feb 1, 1994·Immunology Today·U HolmskovJ C Jensenius
Feb 1, 1993·Current Opinion in Immunology·K Sastry, R A Ezekowitz
Apr 1, 1996·Arthritis and Rheumatism·Y L LauM W Turner

❮ Previous
Next ❯

Citations

Aug 31, 2000·Biochemical and Biophysical Research Communications·S JüligerJ F Kun
Feb 22, 2008·Molecular Diagnosis & Therapy·DianLiang ZhangJieShou Li
Oct 6, 2006·Springer Seminars in Immunopathology·John B HarleyKenneth M Kaufman
Jan 25, 2008·Clinical Rheumatology·Odirlei André MonticieloJosé Artur Bogo Chies
Aug 15, 2013·Current Rheumatology Reports·Patrícia Costa-Reis, Kathleen E Sullivan
Jun 1, 2005·The Medical Clinics of North America·Gail S KerrE Nigel Harris
Sep 6, 2003·Journal of Immunological Methods·R SteffensenK Varming
Oct 22, 2003·Molecular Immunology·M W Turner
Jul 10, 1998·Immunology Letters·D C Kilpatrick
May 29, 2003·Human Immunology·Akito TsutsumiTakayuki Sumida
Sep 12, 2002·Biochimica Et Biophysica Acta·David C Kilpatrick
Jan 23, 1999·Current Opinion in Immunology·J B HarleyT W Behrens
Mar 11, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D Babovic-VuksanovicR M Ten
Mar 18, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·Ibsen Bellini Coimbra, Lilian Tereza Lavras Costallat
Sep 5, 2006·Nature Clinical Practice. Rheumatology·Martine Szyper Kravitz, Yehuda Shoenfeld
Jan 6, 2006·Genes and Immunity·P GarredH O Madsen
Dec 11, 2002·Transfusion Medicine·D C Kilpatrick
Oct 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Paul D Thomas, Anish Kejariwal
Dec 23, 1999·Current Opinion in Hematology·C B Foster, S J Chanock
Aug 12, 2005·Current Opinion in Rheumatology·Jennifer A Croker, Robert P Kimberly
Feb 17, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Philippe H Jais
Mar 5, 2008·Nephrology·Sze K YuenKwok L Tong
Jan 28, 2006·Annals of the Rheumatic Diseases·S SaevarsdottirH Valdimarsson
Apr 17, 2001·Annals of the Rheumatic Diseases·Z Y WangS Kumagai
Mar 23, 2004·Annual Review of Immunology·Anthony P MandersonMark J Walport
Oct 17, 2012·Arthritis Research & Therapy·Aditya K PandaBidyut K Das
Oct 12, 2010·The Oncologist·Jessica M van der BolRon H Mathijssen
Jun 20, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Vasileios Kyttaris, George Tsokos
Dec 2, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Rahul MittalXue-Zhong Liu
May 16, 2001·Current Rheumatology Reports·B P Tsao, J M Grossman
Jul 20, 2002·Current Rheumatology Reports·Betty P Tsao
Nov 24, 2005·Current Rheumatology Reports·Vasileios C KyttarisGeorge C Tsokos
Dec 21, 2000·Current Rheumatology Reports·J M Grossman, B P Tsao
Aug 23, 2006·Autoimmunity·M J Lewis, M Botto

❮ Previous
Next ❯

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