Mannose-Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen-Presenting Cells

Chembiochem : a European Journal of Chemical Biology
David StraßburgerPol Besenius

Abstract

A modular route to prepare functional self-assembling dendritic peptide amphiphiles decorated with mannosides, to effectively target antigen-presenting cells, such as macrophages, is reported. The monomeric building blocks were equipped with tetra(ethylene glycol)s (TEGs) or labeled with a Cy3 fluorescent probe. Experiments on the uptake of the multifunctional supramolecular particles into murine macrophages (Mφs) were monitored by confocal microscopy and fluorescence-activated cell sorting. Mannose-decorated supramolecular polymers trigger a significantly higher cellular uptake and distribution, relative to TEG carrying bare polymers. No cytotoxicity or negative impact on cytokine production of the treated Mφs was observed, which emphasized their biocompatibility. The modular nature of the multicomponent supramolecular polymer coassembly protocol is a promising platform to develop fully synthetic multifunctional vaccines, for example, in cancer immunotherapy.

References

Jan 1, 1984·Annual Review of Immunology·E R Unanue
Jan 1, 1996·Current Opinion in Hematology·S Akira, T Kishimoto
Dec 2, 2004·Expert Opinion on Biological Therapy·Tibor KelerMichael W Fanger
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li-Zhen HeRaphael Clynes
Mar 19, 2009·Angewandte Chemie·Marion K Müller, Luc Brunsveld
Sep 23, 2009·Chemical Reviews·Tom F A De GreefE W Meijer
Jan 26, 2010·Chemistry : a European Journal·Jens VoskuhlBart Jan Ravoo
Aug 24, 2010·Chemical Communications : Chem Comm·Marion K MüllerLuc Brunsveld
Oct 12, 2010·Journal of the American Chemical Society·C Remzi BecerDavid M Haddleton
Feb 22, 2012·Science·T AidaS I Stupp
Jul 10, 2012·Biomaterials·Eun-Ho SongDaniel M Ratner
Sep 7, 2012·Angewandte Chemie·Carlo FastingRainer Haag
Sep 12, 2012·Journal of Leukocyte Biology·Luisa Martinez-Pomares
Dec 25, 2012·Chemical Society Reviews·M Carmen GalanOlivier Renaudet
Apr 10, 2013·Angewandte Chemie·Joshua M Fishman, Laura L Kiessling
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Stanley Plotkin
Nov 21, 2014·Organic & Biomolecular Chemistry·Ralph AppelPol Besenius
Jan 15, 2015·Chemistry : a European Journal·Hendrik FrischPol Besenius
Aug 11, 2015·Chemistry & Biology·Brian Belardi, Carolyn R Bertozzi
Nov 12, 2015·Chemistry : a European Journal·Ralph AppelPol Besenius
Dec 26, 2015·Chemical Reviews·Martina DelbiancoPeter H Seeberger
Jan 5, 2016·Chemical Reviews·Elisha KriegBoris Rybtchinski
Jan 27, 2016·ACS Nano·Maarten H BakkerLorenzo Albertazzi
May 28, 2016·Biomacromolecules·Ruben De CoenBruno G De Geest
Aug 29, 2017·Molecular Oral Microbiology·L SongD T Graves

❮ Previous
Next ❯

Citations

Nov 6, 2018·Organic & Biomolecular Chemistry·Richard BoothJavier Montenegro
Jan 24, 2019·Chembiochem : a European Journal of Chemical Biology·Iván GallegoJavier Montenegro
Jan 29, 2019·Chembiochem : a European Journal of Chemical Biology·Michaela PieszkaDavid Y W Ng
Jun 27, 2019·Organic & Biomolecular Chemistry·Ronja Otter, Pol Besenius
Apr 30, 2020·Chemical Communications : Chem Comm·Franka V GruschwitzJohannes C Brendel
Feb 2, 2021·Beilstein Journal of Organic Chemistry·David StraßburgerPol Besenius
May 1, 2021·Advanced Healthcare Materials·Tingxian LiuRoxanne E Kieltyka
Jun 22, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zewei WeiXiao Zhu
May 3, 2019·Macromolecules·René P M LafleurE W Meijer
Aug 8, 2019·Journal of the American Chemical Society·Simone I S HendrikseE W Meijer
Feb 23, 2020·Biomacromolecules·Victorio Saez TalensRoxanne E Kieltyka
Sep 30, 2020·Biomacromolecules·Silvia Varela-AramburuE W Meijer
Sep 15, 2021·Organic & Biomolecular Chemistry·Sandra M C SchoenmakersAnja R A Palmans
Sep 11, 2021·Macromolecular Rapid Communications·Oliver S StachPol Besenius

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

[Rinshō ketsueki] The Japanese journal of clinical hematology
Miwako Narita, Tatsuo Furukara
Scientific American
L A HerzenbergL A Herzenberg
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
Yin-gang ZhangBing Liu
© 2022 Meta ULC. All rights reserved