Mannose hyperbranched dendritic polymers interact with clustered organization of DC-SIGN and inhibit gp120 binding

FEBS Letters
Georges TabaraniFranck Fieschi

Abstract

DC-SIGN (dendritic cell-specific ICAM-3 grabbing non-integrin) is a C-type lectin receptor of dendritic cells and is involved in the initial steps of numerous infectious diseases. Surface plasmon resonance has been used to study the affinity of a glycodendritic polymer with 32 mannoses, to DC-SIGN. This glycodendrimer binds to DC-SIGN surfaces in the submicromolar range. This binding depends on a clustered organization of DC-SIGN mimicking its natural organization as microdomain in the dendritic cells plasma membrane. Moreover, this compound inhibits DC-SIGN binding to the HIV glycoprotein gp120 with an IC50 in the micromolar range and therefore can be considered as a potential antiviral drug.

References

Jun 7, 2002·Journal of Virology·Carmen P AlvarezRafael Delgado
Mar 1, 2003·The Journal of Biological Chemistry·Pierre-Yves LozachRalf Altmeyer
May 27, 2003·Biochimie·Eric DuvergerMichel Monsigny
Sep 2, 2003·Nature Reviews. Immunology·Yvette van Kooyk, Teunis B H Geijtenbeek
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Fátima LasalaRafael Delgado
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ping ZhuKenneth H Roux
Jan 8, 2004·The Journal of Cell Biology·Alessandra CambiCarl G Figdor
Aug 17, 2004·The Journal of Antimicrobial Chemotherapy·Javier Rojo, Rafael Delgado
Oct 29, 2004·The Journal of Biological Chemistry·Hadar FeinbergWilliam I Weis

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Citations

Jun 4, 2013·Biomaterials·Abhijit A Date, Christopher J Destache
Oct 2, 2007·Journal of the American Chemical Society·M Jack Borrok, Laura L Kiessling
Jul 25, 2009·Nature Reviews. Drug Discovery·Beat Ernst, John L Magnani
Jun 9, 2009·The Journal of Biological Chemistry·Georges TabaraniFranck Fieschi
Jan 8, 2013·International Immunology·Juan J Garcia-VallejoYvette van Kooyk
Mar 24, 2011·Future Medicinal Chemistry·Jose J ReinaJavier Rojo
Jun 4, 2013·Advanced Drug Delivery Reviews·Bernd LepeniesSanjiv Sonkaria
Feb 22, 2014·European Journal of Medicinal Chemistry·Tihomir TomašićMarko Anderluh
Jul 18, 2008·Organic & Biomolecular Chemistry·José J ReinaJavier Rojo
Jul 8, 2011·Organic & Biomolecular Chemistry·Manuel AndreiniAnna Bernardi
Feb 16, 2016·Trends in Biotechnology·Sara Sattin, Anna Bernardi
Dec 4, 2014·Expert Review of Clinical Immunology·Nishi ModySuresh P Vyas
May 17, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Laura M EnsignJustin Hanes
Aug 15, 2014·Biochemistry·Kari PedersonJames H Prestegard
Jun 26, 2010·Medicinal Research Reviews·K O François, J Balzarini
Feb 11, 2014·Biomaterials·Norbert VargaAnna Bernardi
Apr 4, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Daniel Sepúlveda-CrespoM Ángeles Muñoz-Fernández
Jan 21, 2016·Annual Review of Biomedical Engineering·Balaji NarasimhanJulia E Vela Ramirez
Aug 9, 2012·Bioconjugate Chemistry·Laure DehuyserAlain Wagner
Nov 19, 2009·Journal of the American Chemical Society·Eva Maria MunozRicardo Riguera
Jan 4, 2013·Biomacromolecules·Joanna LuczkowiakJavier Rojo
Apr 23, 2014·ACS Chemical Biology·Ieva SutkeviciuteFranck Fieschi
Mar 30, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Nagma ParveenFredrik Höök
Nov 19, 2015·Organic & Biomolecular Chemistry·Anita KotarMarko Anderluh
Jan 18, 2008·European Journal of Immunology·Kuo-Ching ShengGeoffrey A Pietersz
Dec 13, 2007·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Jul 26, 2008·Chembiochem : a European Journal of Chemical Biology·Gabriele TimpanoAnna Bernardi
Jul 10, 2008·Chemistry : a European Journal·Anna Bernardi, Pavel Cheshev
May 20, 2020·Chembiochem : a European Journal of Chemical Biology·Pablo ValverdeJesús Jiménez-Barbero
Aug 23, 2008·Chembiochem : a European Journal of Chemical Biology·Jesús AnguloPedro M Nieto
Nov 16, 2010·Molecular Diversity·Nataša ObermajerAnna Bernardi
Jul 1, 2009·Chembiochem : a European Journal of Chemical Biology·Olga Martínez-AvilaSoledad Penadés
May 17, 2012·Viruses·Raveen ParboosingHendrik G Kruger
Aug 15, 2009·Chemistry : a European Journal·Olga Martínez-AvilaSoledad Penadés

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