PMID: 9423832Jan 10, 1998Paper

Mannose induces the release of cytopathic factors from Acanthamoeba castellanii

Infection and Immunity
H LeherJerry Y Niederkorn

Abstract

Acanthamoeba keratitis is a chronic inflammatory disease of the cornea which is highly resistant to many antimicrobial agents. The pathogenic mechanisms of this disease are poorly understood. However, it is believed that the initial phases in the pathogenesis of Acanthamoeba keratitis involve parasite binding and lysis of the corneal epithelium. These processes were examined in vitro, using Acanthamoeba castellanii trophozoites. Parasites readily adhered to Chinese hamster corneal epithelial cells in vitro; however, parasite binding was strongly inhibited by mannose but not by lactose. Although mannose prevented trophozoite binding, it did not affect cytolysis of corneal epithelial cells. Moreover, mannose treatment induced trophozoites to release cytolytic factors that lysed corneal epithelial cells in vitro. These factors were uniquely induced by mannose because supernatants collected from either untreated trophozoites or trophozoites treated with other sugars failed to lyse corneal cells. The soluble factors were size fractionated in centrifugal concentrators and found to be > or = 100 kDa. Treatment of the supernatants with the serine protease inhibitor phenylmethylsulfonyl fluoride inhibited most, but not all, of the cytop...Continue Reading

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Citations

Jul 24, 2004·Journal of Medical Microbiology·James SissonsNaveed Ahmed Khan
Apr 15, 2003·Clinical Microbiology Reviews·Francine Marciano-Cabral, Guy Cabral
Mar 5, 2015·The Journal of Eukaryotic Microbiology·Gerardo Ramírez-RicoJesús Serrano-Luna
Aug 24, 1999·Springer Seminars in Immunopathology·J Y NiederkornJ P McCulley
Jul 30, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Raman Kumar, David Lloyd
Mar 17, 2006·Canadian Journal of Microbiology·José de Jesús Serrano-LunaMineko Shibayama
Nov 24, 2011·Ocular Immunology and Inflammation·Suggerappa Laxmanappa Hoti, Veena Tandon
Jan 7, 2009·Eye & Contact Lens·Hassan AlizadehH Dwight Cavanagh
Jul 15, 2015·Eye·M-A TaubeP Hossain
Apr 5, 2011·The Korean Journal of Parasitology·Abdul Matin, Suk-Yul Jung
Jul 12, 2008·FEMS Microbiology Letters·Ricky DudleyNaveed Ahmed Khan
Jan 17, 2007·Eye & Contact Lens·Shady T AwwadH Dwight Cavanagh
Jan 17, 2007·Applied Microbiology and Biotechnology·Ricky DudleyNaveed Ahmed Khan
May 5, 2017·PloS One·Steven HuthChristine Selhuber-Unkel
Dec 24, 2018·Parasite Immunology·Antonella CanoCraig W Roberts
Nov 23, 2020·Experimental Eye Research·Jerry Y Niederkorn
Jun 22, 1999·Experimental Eye Research·H LeherJ Y Niederkorn
Jun 5, 2003·Microbial Pathogenesis·Naveed Ahmed Khan
Aug 18, 2004·International Journal for Parasitology·Frederick L Schuster, Govinda S Visvesvara
May 16, 2006·Microbes and Infection·Daniel W Clarke, Jerry Y Niederkorn
Feb 28, 2006·Trends in Parasitology·Daniel W Clarke, Jerry Y Niederkorn

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