Oct 17, 2001

Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium

The Journal of Experimental Medicine
Heikki IrjalaSirpa Jalkanen


Continuous lymphocyte recirculation between blood and lymphoid tissues forms a basis for the function of the immune system. Lymphocyte entrance from the blood into the tissues has been thoroughly characterized, but mechanisms controlling lymphocyte exit from the lymphoid tissues via efferent lymphatics have remained virtually unknown. In this work we have identified mannose receptor (MR) on human lymphatic endothelium and demonstrate its involvement in binding of lymphocytes to lymphatic vessels. We also show that the binding requires L-selectin, and L-selectin and MR form a receptor-ligand pair. On the other hand, L-selectin binds to peripheral lymph node addressins (PNAds) on high endothelial venules (HEVs) that are sites where lymphocytes enter the lymphatic organs. Interestingly, MR is absent from HEVs and PNAds from lymphatic endothelium. Thus, lymphocyte L-selectin uses distinct ligand molecules to mediate binding at sites of lymphocyte entrance and exit within lymph nodes. Taken together, interaction between L-selectin and MR is the first molecularly defined mechanism mediating lymphocyte binding to lymphatic endothelium.

Mentioned in this Paper

Immune System
CD206 antigen
Magnetic Resonance Imaging
Mice, Inbred BALB C
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Hormone Receptors, Cell Surface
Hepatitis E virus
Set of Efferent Lymphatic Vessels
Lymphoid Cells

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