Mannose-sensitive and mannose-resistant adherence to human uroepithelial cells and urinary virulence of Escherichia coli.

Infection and Immunity
J F van der BoschD M MacLaren

Abstract

The adherence to human uroepithelial cells of 23 Escherichia coli strains belonging to three groups with different levels of virulence was investigated, and the mechanism of adherence was studied. It was found that strains belonging to the most virulent group adhered better to human uroepithelial cells than did avirulent strains. Adherence of loss virulent but supposedly nephropathogenic strains was more variable. These results suggest that adherence is an important virulence factor, especially in the group of strains with the highest but a more general virulence. Piliated strains adhered better than did nonpiliated strains. We found strong evidence for the existence of at least two different mechanisms of adherence: (i) mannose-sensitive adherence by piliated strains, very likely mediated by type I pili because this mannose-sensitive adherence was associated with mannose-sensitive hemagglutination of guinea pig erythrocytes by broth cultures of the strains; (ii) mannose-resistant adherence by piliated strains, very likely mediated by non-type I pili because this mannose-resistant adherence was invariably associated with mannose-resistant hemagglutination of human group A erythrocytes by the strains, whether grown in broth or o...Continue Reading

References

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Citations

Nov 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R J Roche, E R Moxon
Dec 11, 1997·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J Vranes
Aug 5, 2004·Journal of Bacteriology·Albrecht LudwigWerner Goebel
Apr 23, 2020·Scientific Reports·Amy L BottomleyElizabeth J Harry
Jan 1, 1986·Scandinavian Journal of Urology and Nephrology·C Svanborg Edén
Jun 1, 1986·The Journal of Urology·W J HopkinsE Balish
Apr 1, 1987·The Journal of Urology·R J SzaboT A Stamey
Jul 1, 1986·Journal of Clinical Microbiology·J M de ReeJ F van den Bosch
Mar 1, 1993·Infection and Immunity·J F van den BoschF K de Graaf
May 1, 1984·Infection and Immunity·R F Melhem, P T LoVerde
Jan 1, 1991·Clinical Microbiology Reviews·J R Johnson
Aug 1, 1984·Journal of Bacteriology·P E Orndorff, S Falkow
Sep 1, 1987·Infection and Immunity·J M de Ree, J F van den Bosch

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