PMID: 11912051Mar 26, 2002Paper

Mannosomes: a molluscan intracellular tubular membrane system related to heavy metal stress?

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Thomas KniggeM Connock

Abstract

Amongst animals, several hydrogen peroxide-generating oxidases are apparently restricted to molluscs. One of these, D-mannitol oxidase, is concentrated in the alimentary system, where it is associated with its own subcellular membrane system of unique tubular morphology, most likely representing a structural modification of the ER. These structures can be purified by subcellular fractionation and have been termed 'mannosomes'. Little is known about the functions of mannitol oxidase or of mannosomes, but the previously reported molluscicide-induced increase in mannosomes implies their involvement in a general stress reaction. In this study, we examined the effects of heavy metal stress in the terrestrial gastropod Arion lusitanicus. The activity of mannitol oxidase and mannosome abundance were monitored, together with metal effects on heat-shock protein level, and these parameters were compared to heavy metal accumulation in the digestive gland. We found that mannitol oxidase is inhibited by heavy metals more than other oxidases. On the other hand, hsp70 levels and mannosomal protein were increased with enhanced heavy metal stress, the latter indicating a probable increase in the number of mannosome organelles. Thus, stress prot...Continue Reading

References

Jan 1, 1986·The International Journal of Biochemistry·J E VorhabenJ W Campbell
May 8, 1998·Cell Biology International·I Cancio, M P Cajaraville
Mar 4, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·M MatsuokaH Igisu
Jul 25, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·N GrewalM Connock
May 1, 1983·Journal of Morphology·E W Kitajima, W L Paraense

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Citations

Nov 5, 2003·Journal of Biochemical and Molecular Toxicology·Indranil MukhopadhyayD Kar Chowdhuri
Jan 8, 2005·Science·Olivier Lespinet, Bernard Labedan

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