Mannosylated superoxide dismutase inhibits hepatic reperfusion injury in rats

The Journal of Surgical Research
S KondoT Kanematsu

Abstract

Superoxide anion radical (O2-) is one factor related to ischemia/reperfusion injury to the liver. The sites of O2- production and injury have yet to be determined. Superoxide dismutase (SOD), a specific scavenger for O2-, has an inhibitory effect on injury caused by O2-. SOD is of low molecular weight; hence, it has a short half-life in the circulating blood. Mannosylated SOD is taken up in sinusoidal endothelial cells of the liver by receptor-mediated endocytosis. In rats with an occluded inflow against 70% of the liver for 30 min followed by reperfusion there were elevations of serum aspartate aminotransferase and alanine aminotransferase, and lipid peroxide concentrations in liver tissue were significantly inhibited by intravenous administration of mannosylated SOD compared to treatment with normal saline. Electron microscopic examination showed that mannosylated SOD protected against damage to the sinusoidal endothelial cells caused by ischemia/reperfusion and that conventional SOD had no such protective effect. Thus, O2- produced by ischemia/reperfusion apparently damages sinusoidal endothelial cells, and damage to hepatic parenchymal cells is secondary. Mannosylated SOD deserves further study for possible use in surgical ...Continue Reading

Citations

Oct 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Dean M AnselmoDouglas G Farmer
Dec 3, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Masahiro UshitoraHiroyuki Mizuguchi
Sep 12, 1998·The Journal of Surgical Research·N KimuraK Doi
Jun 29, 1999·The Journal of Surgical Research·T KondoK Messmer
Oct 3, 2007·Journal of Hepato-biliary-pancreatic Surgery·Hiroyuki InuoTakashi Kanematsu
Jul 20, 2002·The Journal of Surgical Research·Roberto Anaya-PradoPeter A Ward
Mar 20, 2003·The Journal of Surgical Research·Atsushi MorisueMasaki Kitajima
Sep 19, 2003·The Journal of Surgical Research·Kousyou YamanouchiTakashi Kanematsu

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