Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete

Journal of Natural Products
Usama W HawasHartmut Laatsch

Abstract

Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)-5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.

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Citations

May 1, 2010·The Journal of Antibiotics·Clarisse Blandine Fotso Fondja YaoHartmut Laatsch
Dec 1, 2010·Marine Drugs·Ira Bhatnagar, Se-Kwon Kim
Dec 1, 2010·Marine Drugs·Ira Bhatnagar, Se-Kwon Kim
Jan 11, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juana Andrea IbacacheJaime A Valderrama
Aug 20, 2015·Marine Drugs·Natalie Netz, Till Opatz
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Feb 9, 2017·Bioorganic & Medicinal Chemistry Letters·Amalyn Nain-PerezRené Csuk
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Jun 9, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Virginia DelgadoJaime A Valderrama
Sep 15, 2010·Natural Product Reports·Minoru IshikuraTakumi Abe
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