Mantle cell lymphoma-Advances in molecular biology, prognostication and treatment approaches.

Hematological Oncology
Elisabeth Silkenstedt, Martin Dreyling

Abstract

Mantle cell lymphoma (MCL) is clinically characterized by its heterogenous behavior with courses ranging from indolent cases that do not require therapy for years to highly aggressive MCL with very limited prognosis. A better understanding of the complex biology of MCL has already led to the approval of several innovative agents, expanding the landscape of MCL therapies and improving therapeutic options especially for refractory or relapsed disease. Nevertheless, to further optimize MCL treatment, early identification of individual risk profile and risk-adapted, patient-tailored choice of therapeutic strategy needs to be prospectively incorporated in clinical patient management. This review highlights recent advances in deciphering the molecular background of MCL, the definition of prognostically relevant factors and the identification of potential druggable targets and summarizes current treatment recommendations for primary and relapsed/refractory MCL including novel targeted therapies.

References

Oct 27, 2007·Blood·Eva HosterUNKNOWN European Mantle Cell Lymphoma Network
Feb 4, 2010·Cancer Research·Verònica FernàndezElías Campo
Aug 10, 2012·The New England Journal of Medicine·H C Kluin-NelemansM H Dreyling
Oct 2, 2012·The Journal of Clinical Investigation·Pedro JaresElias Campo
Jun 21, 2013·The New England Journal of Medicine·Michael L WangKristie A Blum
Jan 15, 2016·Blood·Peter MartinKristie A Blum
Mar 2, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eva HosterWolfram Klapper
Sep 28, 2017·The New England Journal of Medicine·Steven Le GouillUNKNOWN LYSA Group
Mar 29, 2018·The New England Journal of Medicine·Constantine S TamAndrew W Roberts
Dec 6, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hanneke C Kluin-NelemansMartin H Dreyling
Apr 4, 2020·The New England Journal of Medicine·Michael WangPatrick M Reagan
Jul 1, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M DreylingUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org

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