Mantle cell lymphoma in a tubular adenoma: unusual presentation with synchronous colonic carcinoma

Annals of Diagnostic Pathology
Ignacio SztarkierDaniel Benharroch

Abstract

An 80-year-old man underwent sigmoidectomy for adenocarcinoma. Six months later, after a near-syncope incident, pancytopenia was detected in the absence of occult blood in the stools. A bone marrow biopsy showed malignant lymphoma, suggestive of mantle cell lymphoma (MCL). Colonoscopy at this time revealed 3 colonic tubular adenomas. Reassessment of the histology of the colonic polyps and appropriate immunohistochemical stains showed that the lamina propria of one of the tubular adenomas was infiltrated by MCL. Reexamination of the sections taken at the time of the original sigmoidectomy showed MCL in 2 of the regional lymph nodes removed at that time, but no evidence of lymphoma in the colon was found. To our knowledge, this is the fifth reported case of synchronous occurrence of intestinal MCL and colonic carcinoma and the first report of MCL presenting in a tubular adenoma of the colon.

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Citations

Aug 17, 2010·World Journal of Surgical Oncology·Nikolaos SikaliasNikolaos Ekonomou
Nov 19, 2013·Annals of Diagnostic Pathology·Adriana Handra-Luca
Sep 12, 2015·International Journal of Surgical Pathology·Amy A LoGuang-Yu Yang
Feb 23, 2019·Case Reports in Gastroenterology·Qiao YuDian-Zhong Luo

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