Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass

Environmental Health Perspectives
Eva Oberdörster

Abstract

Although nanotechnology has vast potential in uses such as fuel cells, microreactors, drug delivery devices, and personal care products, it is prudent to determine possible toxicity of nanotechnology-derived products before widespread use. It is likely that nanomaterials can affect wildlife if they are accidentally released into the environment. The fullerenes are one type of manufactured nanoparticle that is being produced by tons each year, and initially uncoated fullerenes can be modified with biocompatible coatings. Fullerenes are lipophilic and localize into lipid-rich regions such as cell membranes in vitro, and they are redox active. Other nano-sized particles and soluble metals have been shown to selectively translocate into the brain via the olfactory bulb in mammals and fish. Fullerenes (C60) can form aqueous suspended colloids (nC60); the question arises of whether a redox-active, lipophilic molecule could cause oxidative damage in an aquatic species. The goal of this study was to investigate oxyradical-induced lipid and protein damage, as well as impacts on total glutathione (GSH) levels, in largemouth bass exposed to nC60. Significant lipid peroxidation was found in brains of largemouth bass after 48 hr of exposure...Continue Reading

References

Jul 1, 1995·Pharmacology & Toxicology·H TjälveK Borg-Neczak
Jun 11, 2002·Biochemical and Biophysical Research Communications·Sarah FoleyChristian Larroque
Apr 5, 2003·Environmental Health Perspectives·Ning LiAndre Nel
Oct 2, 2003·Nature Biotechnology·Vicki L Colvin
Jun 19, 2004·Inhalation Toxicology·G OberdörsterC Cox
Oct 24, 1941·Science·J R PaulA E Casey
Jan 1, 2004·Nano Letters·Austin M DerfusSangeeta N Bhatia

❮ Previous
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Citations

Dec 1, 2007·Biointerphases·Cristina BuzeaKevin Robbie
Aug 31, 2012·Nanomedicine·Suwussa BamrungsapWeihong Tan
Aug 25, 2007·Nanomedicine·Roland Clift
Dec 24, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sandra M SantosRomeu A Videira
Jul 11, 2013·Nanomedicine·Anthony DellingerChristopher L Kepley
Aug 25, 2007·Nanomedicine·Paul J A Borm, Detlef Müller-Schulte
Dec 5, 2013·Physiological Reports·Rajaa HussienGeorge A Brooks
Jun 1, 2013·ISRN Toxicology·Sachindri Rana, P T Kalaichelvan
Aug 13, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Ebabe ElleJ M Rouanet
Mar 1, 2014·Environmental Toxicology and Pharmacology·Fude WangYongji Yang
Jan 16, 2014·Journal of Hazardous Materials·Te-Hao ChenPei-Jie Meng
Oct 19, 2011·Investigational New Drugs·Marlein Miranda ConaYicheng Ni
Mar 21, 2008·Ecotoxicology·Richard D HandyMark Crane
Sep 7, 2014·Molecular Immunology·Ruchi RoyPremendra D Dwivedi
Sep 10, 2014·Marine Environmental Research·Giovanni Libralato
Mar 4, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Qasim ChaudhryRichard Watkins
Jul 9, 2005·Environmental Health Perspectives·Günter OberdörsterJan Oberdörster
Nov 17, 2006·Environmental Health Perspectives·Shosaku Kashiwada
Dec 16, 2006·Journal of Nanobiotechnology·Nicole LeviGaddamanugu L Prasad
Jan 23, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jamie L GilmoreAlexander V Kabanov
Jul 16, 2008·Bulletin of Environmental Contamination and Toxicology·Taylor M IngleRoger A Buchanan
Aug 9, 2008·International Journal of Nanomedicine·Wim H De Jong, Paul J A Borm
Oct 31, 2008·Environmental Health : a Global Access Science Source·Jean-Paul BourdineaudMuriel Laclau
Apr 25, 2009·BMC Plant Biology·Eduardo CorredorMaría-Carmen Risueño
Jun 19, 2009·ACS Nano·Christopher V KellyMark M Banaszak Holl
Sep 15, 2009·Environmental Science & Technology·Michael KovochichMark R Wiesner
Sep 22, 2009·Environmental Science & Technology·Carl W IsaacsonJennifer A Field
Dec 17, 2009·International Journal of Nanomedicine·Ranga Partha, Jodie L Conyers
Apr 3, 2010·Reproductive Biology and Endocrinology : RB&E·Xiaohui LiuJiayin Liu
Oct 19, 2010·Applied and Environmental Microbiology·Alex N HadduckAlan T Bakalinsky
Dec 3, 2010·Journal of Nanoscience and Nanotechnology·Jie MengXing-Jie Liang
Jun 28, 2011·The Journal of Biological Chemistry·Prabakaran RavichandranGovindarajan T Ramesh
Oct 22, 2011·International Journal of Molecular Sciences·Tin-Tin Win-Shwe, Hidekazu Fujimaki
May 19, 2012·International Journal of Nanomedicine·Faiza SharifMichael K Richardson
May 29, 2009·Archives of Toxicology·Tomoyuki Sumizawa, Hideki Igisu
Apr 15, 2008·Ecotoxicology·Richard D HandyCharles R Tyler

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Methods Mentioned

BETA
protein oxidation assay
protein assay

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