Manufactured nanoparticles: their uptake and effects on fish--a mechanistic analysis.

Ecotoxicology
Richard D HandyCharles R Tyler

Abstract

There is an emerging literature reporting toxic effects of manufactured nanomaterials (NMs) and nanoparticles (NPs) in fish, but the mechanistic basis of both exposure and effect are poorly understood. This paper critically evaluates some of the founding assumptions in fish toxicology, and likely mechanisms of absorption, distribution, metabolism and excretion (ADME) of NPs in fish compared to other chemicals. Then, using a case study approach, the paper compares these assumptions for two different NPs; TiO2 and C60 fullerenes. Adsorption of NPs onto the gill surface will involve similar processes in the gill microenvironment and mucus layer to other substances, but the uptake mechanisms for NPs by epithelial cells are more likely to occur via vesicular processes (e.g., endocytosis) than uptake on membrane transporters or by diffusion through the cell membranes. Target organs may include the gills, gut, liver and sometimes the brain. Information on metabolism and excretion of NPs in fish is limited; but hepatic excretion into the bile seems a more likely mechanism, rather than mainly by renal or branchial excretion. TiO2 and C60 share some common chemical properties that appear to be associated with some similar toxic effects, ...Continue Reading

References

Feb 20, 1978·Journal of Theoretical Biology·T J Pedley, J Fischbarg
Jul 1, 1992·Environmental Health Perspectives·G OberdörsterJ Finkelstein
Feb 1, 1996·Toxicology Letters·K Borg-Neczak, H Tjälve
Oct 1, 1996·Antimicrobial Agents and Chemotherapy·P RajagopalanF D Boudinot
Nov 18, 2000·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·N MiyataI Nakanishi
Mar 7, 2002·The Biochemical Journal·Hui DengKe-He Ruan
Nov 8, 2002·Biochimica Et Biophysica Acta·Chris M WoodPeter Pärt
Nov 14, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Paul R PaquinKuen Benjamin Wu
Jul 10, 2003·Current Opinion in Biotechnology·Mihail C Roco
Oct 2, 2003·Nature Biotechnology·Vicki L Colvin
Nov 6, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Edilberto BermudezJeffrey I Everitt
Oct 27, 2004·Ultrasonics Sonochemistry·Katsuhiko HiranoKatsuya Sawada
Jun 30, 2005·Environmental Science & Technology·J D FortnerJ B Hughes
Jul 12, 2005·Biomaterials·Christie M SayesVicki L Colvin
Jul 19, 2005·Journal of Colloid and Interface Science·M A Barakat
Sep 24, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·D B WarheitK L Reed
Sep 27, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A O GamerB van Ravenzwaay
Feb 24, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·David B WarheitKenneth L Reed
Mar 31, 2006·Environmental Science & Technology·Kun YangBaoshan Xing
Apr 25, 2006·Environmental Toxicology and Chemistry·Sarah B Lovern, Rebecca Klaper
Nov 17, 2006·Environmental Health Perspectives·Shosaku Kashiwada
Apr 19, 2007·Environmental Science & Technology·Jaesang LeeJae-Hong Kim
Apr 24, 2007·Environmental Toxicology and Chemistry·Jinping ChengShuk Han Cheng
Jun 26, 2007·Environmental Health Perspectives·Günter OberdörsterJan Oberdörster
Aug 1, 2007·Journal of Nanoscience and Nanotechnology·Chidananda S SharmaGovindarajan T Ramesh
Sep 19, 2007·Environmental Science & Technology·Richard Owen, Richard Handy
Jan 12, 2008·Environmental Science & Technology·Robert J GriffittDavid S Barber
Mar 21, 2008·Ecotoxicology·Richard D HandyMark Crane

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Citations

Nov 7, 2008·Analytical and Bioanalytical Chemistry·Marinella FarréDamià Barceló
Dec 2, 2010·Ecotoxicology·Lars-Henrik HeckmannJaneck J Scott-Fordsmand
Aug 13, 2013·Ecotoxicology and Environmental Safety·Gloria IsaniGiancarlo Falcioni
Feb 23, 2013·Analytical Chemistry·Melissa A Maurer-JonesChristy L Haynes
Jun 15, 2011·Environmental Science & Technology·Zhenyu WangBaoshan Xing
May 2, 2012·Environmental Science & Technology·Helen C PoyntonShekar Govindasmawy
Mar 11, 2011·Journal of Toxicology and Environmental Health. Part a·Kevin V ThomasKnut-Erik Tollefsen
Apr 1, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tessa M ScownCharles R Tyler
Mar 12, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tessa M ScownCharles R Tyler
Feb 22, 2013·Journal of the Royal Society, Interface·Lennart TreuelGerd Ulrich Nienhaus
Jul 26, 2013·Journal of the Royal Society, Interface·Renata BehraBarbara Rothen-Rutishauser
Jul 13, 2012·Environmental Health : a Global Access Science Source·Suchi SmitaQamar Rahman
Aug 13, 2013·Environmental Health Perspectives·Talia E Abbott ChalewKellogg J Schwab
Jun 23, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Sherrill L MacuraBrooke T Mossman
Mar 29, 2014·Environmental Science & Technology·M MarmiroliN Marmiroli
Feb 6, 2009·Nanomedicine·Melissa A Maurer-JonesChristy L Haynes
Jan 25, 2014·Journal of Hazardous Materials·Youn-Joo JungSang D Kim
Apr 2, 2014·Environmental Science & Technology·Natàlia Garcia-ReyeroEdward J Perkins
Dec 21, 2013·In Vitro Cellular & Developmental Biology. Animal·Nguyen T K VoLucy E J Lee
Apr 8, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Christopher Anthony DieniTyson James Maccormack
Jun 18, 2014·Environmental Science & Technology·Jian Wang, Wen-Xiong Wang
Jan 16, 2014·Journal of Hazardous Materials·Te-Hao ChenPei-Jie Meng
Sep 24, 2015·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Nanna B HartmannJuan M Riego Sintes
Jul 26, 2014·Environmental Toxicology·Lei ShengFashui Hong
Mar 7, 2012·Marine Environmental Research·Valeria Matranga, Ilaria Corsi
Jan 24, 2012·The Science of the Total Environment·Lex RoesChristian Ludwig
Dec 14, 2011·Ecotoxicology and Environmental Safety·Chi Hoa PhamMan Bock Gu
Apr 18, 2015·Environmental Pollution·Boris JovanovićDušan Palić
Apr 9, 2011·Environment International·Benjamin J Shaw, Richard D Handy

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