Manufacturing Mesenchymal Stromal Cells for the Treatment of Graft-versus-Host Disease: A Survey among Centers Affiliated with the European Society for Blood and Marrow Transplantation.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Cristina TrentoFrancesco Dazzi

Abstract

The immunosuppressive properties of mesenchymal stromal cells (MSC) have been successfully tested to control clinical severe graft-versus host disease and improve survival. However, clinical studies have not yet provided conclusive evidence of their efficacy largely because of lack of patients' stratification criteria. The heterogeneity of MSC preparations is also a major contributing factor, as manufacturing of therapeutic MSC is performed according to different protocols among different centers. Understanding the variability of the manufacturing protocol would allow a better comparison of the results obtained in the clinical setting among different centers. In order to acquire information on MSC manufacturing we sent a questionnaire to the European Society for Blood and Marrow Transplantation centers registered as producing MSC. Data from 17 centers were obtained and analyzed by means of a 2-phase questionnaire specifically focused on product manufacturing. Gathered information included MSC tissue sources, MSC donor matching, medium additives for ex vivo expansion, and data on MSC product specification for clinical release. The majority of centers manufactured MSC from bone marrow (88%), whilst only 2 centers produced MSC fro...Continue Reading

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Citations

Aug 23, 2019·Bone Marrow Transplantation·Mayela MendtElizabeth Shpall
Sep 22, 2020·World Journal of Stem Cells·Jing-Hua WangShu-Shan Yan
Jan 1, 2020·Journal of Translational Medicine·Sandra Laner-PlambergerKatharina Schallmoser
Jun 13, 2020·Frontiers in Pharmacology·Darshana S CherianTracy S P Heng
Jul 17, 2020·Frontiers in Immunology·Tik Shing CheungAntonio Galleu
Dec 1, 2019·Journal of Translational Medicine·Soukaina BahsounElizabeth C Akam
Mar 28, 2019·Stem Cells International·Sara NavaGiulio Alessandri
Feb 9, 2021·Frontiers in Bioengineering and Biotechnology·A HagenJ Burk
Feb 10, 2021·Journal of Pediatric Hematology/oncology·Mikhail KiselevskiySvetlana Varfolomeeva
Jun 3, 2021·International Journal of Molecular Sciences·Michaela OellerKatharina Schallmoser
Jun 28, 2019·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Sümeyye ElgazPeter Bader

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Methods Mentioned

BETA
flow cytometry

Clinical Trials Mentioned

NCT00366145
NCT02336230

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