Many roads lead to oncogene-induced senescence

Oncogene
Stéphanie Courtois-CoxKaren Cichowski

Abstract

Oncogene-induced senescence is a mechanism of tumor suppression that restricts the progression of benign tumors. Important advances have been made toward elucidating the mechanisms that regulate this response; however, there is presently no unified model that integrates all current findings. DNA damage, replicative stress, reactive oxygen species, heterochromatin formation and negative feedback signaling networks have all been proposed to play an integral role in promoting senescence in response to various oncogenic insults. In all cases, these signals have been shown to function through Rb and p53, but utilize different intermediaries. Thus, it appears that senescence is not triggered by a single, linear series of events, but instead is regulated by a complex signaling network. Accordingly, multiple proteins may cooperate to establish a senescence response, but the limiting signal(s) may be dictated by the initiating genetic alteration and/or tissue type. This review will focus on integrating current models and will highlight data that provide new insight into the signals that function to suppress human tumor development.

References

Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C J DerG M Cooper
Mar 13, 1999·The Journal of Biological Chemistry·A C LeeT Finkel
Jul 12, 2003·Nature Cell Biology·Simona ParrinelloJudith Campisi
Dec 24, 2003·PLoS Biology·Lloyd C TrotmanPier Paolo Pandolfi
Jun 3, 2004·Nature Reviews. Molecular Cell Biology·Hong Joo Kim, Dafna Bar-Sagi
Oct 1, 2004·Molecular and Cellular Biology·Ann MacLarenDavid A F Gillespie
Dec 4, 2004·Nature·Chaowei WuKonstantin Galaktionov
Mar 2, 2005·Nature Reviews. Cancer·J Martin Brown, Laura D Attardi
Mar 16, 2005·Molecular and Cellular Biology·Saskia M BrachmannLewis C Cantley
Mar 16, 2005·Molecular and Cellular Biology·Eros Lazzerini DenchiKristian Helin
Jun 23, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Friedegund MeierMeenhard Herlyn
Aug 5, 2005·Nature·Manuel ColladoManuel Serrano
Aug 5, 2005·Nature·Melanie BraigClemens A Schmitt
Aug 5, 2005·Nature·Chrysiis MichaloglouDaniel S Peeper
Feb 14, 2006·Cancer Letters·Ting Ling LoGraeme R Guy
May 9, 2006·Nature·Lloyd C TrotmanPier Paolo Pandolfi
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·C F B KimT Jacks
Sep 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Owen J SansomAlan R Clarke
Nov 15, 2006·Cancer Biology & Therapy·Ryungsa KimKazuaki Tanabe
Dec 1, 2006·Nature·Raffaella Di MiccoFabrizio d'Adda di Fagagna
Dec 13, 2006·Cancer Cell·Stéphanie Courtois-CoxKaren Cichowski
Jan 11, 2007·Genes & Development·Michael T Hemann, Masashi Narita
Jan 11, 2007·Genes & Development·Frédérick A MalletteGerardo Ferbeyre
Jan 26, 2007·Nature·Andrea VenturaTyler Jacks
Feb 13, 2007·Cancer Cell·Ignacio DoladoAngel R Nebreda
Mar 21, 2007·Genes & Development·Alice T ShawTyler Jacks

❮ Previous
Next ❯

Citations

Jul 18, 2009·Biogerontology·Alvaro Macieira-Coelho
Dec 25, 2010·Pituitary·Agostino PaolettaGiacomo Tirabassi
Mar 6, 2013·Journal of Proteome Research·Susan FanayanEdouard Nice
Sep 13, 2011·Acta Pharmacologica Sinica·Yi Zhang, Jin-ming Yang
Aug 22, 2009·Cell Death and Differentiation·N R ChristoffersenA H Lund
Dec 17, 2009·Oncogene·A F CheungT Jacks
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rocky CiprianoMark W Jackson
Dec 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Huifang SunDavid W Goodrich
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Agustin ChicasScott W Lowe
Feb 17, 2010·The Journal of Biological Chemistry·Youjun LiEdward V Prochownik
Jan 18, 2011·Carcinogenesis·Laura López-VicenteSantiago Ramon Y Cajal
Jul 9, 2009·Human Molecular Genetics·Jenny A WatsonAmanda McCann
Feb 13, 2010·Neuro-oncology·Marie-Thérése StockhausenHans Skovgaard Poulsen
Sep 17, 2010·Genes & Development·Michael M Shen, Cory Abate-Shen
Apr 19, 2011·Genes & Development·Katrin TschöpNicholas Dyson
Sep 21, 2010·Biological Reviews of the Cambridge Philosophical Society·Amancio Carnero, Matilde E Lleonart
Dec 2, 2008·Pigment Cell & Melanoma Research·Hunter W Richards, Estela E Medrano
May 21, 2011·Science·Roberto Zoncu, David M Sabatini
Jul 22, 2010·Molecular Cancer Research : MCR·Marina ZemskovaAndrew S Kraft
Nov 23, 2012·Cancer Discovery·Ophélia MaertensKaren Cichowski
Mar 5, 2013·The Journal of Clinical Investigation·Tamara TchkoniaJames L Kirkland
Sep 11, 2013·The Journal of Clinical Investigation·Kwan-Hyuck BaekSandra Ryeom
Apr 23, 2013·Cell Communication and Signaling : CCS·Michal SmidaJonathan A Lindquist
Jul 20, 2011·Cell & Bioscience·Susann LudwigAria Baniahmad
Nov 3, 2009·Molecular Endocrinology·Heng-Yu Fan, Joanne S Richards
Apr 28, 2010·PloS One·Gabriela Gutierrez-ReyesDavid Kershenobich
Jun 17, 2011·Future Oncology·Marco A Velasco-VelázquezRichard G Pestell
Mar 26, 2014·Cancers·Nadiya SosonkinaJong-In Park
Mar 29, 2014·Cancers·Damian J JunkMark W Jackson
Jul 8, 2014·Frontiers in Biology·Jong-In Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.