Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells.

Planta medica
Jayavardhana R PalemShao-chung V Hsia

Abstract

This study investigated the putative inhibitory effect of manzamine A on HSV-1 infection. Our results indicated that manzamine A effectively inhibited viral replication and infection in the cell line SIRC, a corneal cell line, at 1 µM. The existing anti-HSV-1 drug acyclovir was analyzed and showed a comparable activity at 50 µM. Plaque assays demonstrated that manzamine A reduced the release of infectious virus by 10 (11)-fold. RTPCR assays indicated that HSV-1 virion host shutoff (vhs) activity and ICP0 transcription were decreased by manzamine A treatment. These results bode well for the development of manzamines as potential leads to reduce viral infection in corneal cells and to prevent HSV-1-induced eye infections such as keratitis.

Citations

Oct 3, 2014·Journal of Immunology Research·Jacek Rolinski, Iwona Hus
Jun 11, 2015·The Journal of Pharmacy and Pharmacology·Sherif T S HassanKateřina Berchová
Jun 28, 2014·Chinese Journal of Natural Medicines·Shi QiuXi-Jun Wang
Jul 23, 2016·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Jayavardhana R PalemKhalid A El Sayed
Aug 8, 2019·Brazilian Journal of Biology = Revista Brasleira De Biologia·C LhullierE P Schenkel
Jul 11, 2020·Biomolecules·Gennaro RiccioChiara Lauritano
May 1, 2021·Marine Drugs·Disha VarijakzhanChou-Min Chong
Nov 7, 2020·European Journal of Medicinal Chemistry·Mariana C AlmeidaEmília Sousa

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