MAO-A Phenotype Effects Response Sensitivity and the Parietal Old/New Effect during Recognition Memory

Frontiers in Human Neuroscience
Robert S RossErika Nyhus

Abstract

A critical problem for developing personalized treatment plans for cognitive disruptions is the lack of understanding how individual differences influence cognition. Recognition memory is one cognitive ability that varies from person to person and that variation may be related to different genetic phenotypes. One gene that may impact recognition memory is the monoamine oxidase A gene (MAO-A), which influences the transcription rate of MAO-A. Examination of howMAO-Aphenotypes impact behavioral and event-related potentials (ERPs) correlates of recognition memory may help explain individual differences in recognition memory performance. Therefore, the current study uses electroencephalography (EEG) in combination with genetic phenotyping of theMAO-Agene to determine how well-characterized ERP components of recognition memory, the early frontal old/new effect, left parietal old/new effect, late frontal old/new effect, and the late posterior negativity (LPN) are impacted byMAO-Aphenotype during item and source memory. Our results show that individuals with theMAO-Aphenotype leading to increased transcription have lower response sensitivity during both item and source memory. Additionally, during item memory the left parietal old/new...Continue Reading

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Citations

Sep 26, 2019·Frontiers in Human Neuroscience·Erika NyhusIsabella Marie Wang Vakkur
Jul 6, 2021·Perceptual and Motor Skills·Aiqing NiePeipeng Liang

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Methods Mentioned

BETA
genotyping

Software Mentioned

Prime
SPSS
ERPLab
EEGLAB

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