PMID: 6405286Feb 1, 1983Paper

MAO-B inhibitor deprenyl and beta-phenylethylamine potentiate [D-ALA2]-Met-enkephalinamide-induced seizures

Naunyn-Schmiedeberg's Archives of Pharmacology
O E UkponmwanM Dzoljic


The relationship between deprenyl (MAO-B inhibitor), beta-phenylethylamine (PEA, MAO-B substrate) and [D-Ala2]-Met-enkephalinamide (DALA)-induced seizure was studied in the urethane-anaesthetized rats. A combined electromyographic (EMG) and electrocorticographic (ECoG) method was used. PEA (20-100 micrograms ivt) or DALA (10 micrograms ivt) induced myoclonic contractions (MC) in the submandibular muscle and epileptiform pattern with spike activity in the ECoG. Administration of subconvulsant doses of PEA (5-10 micrograms ivt 0.5-1 min before DALA) significantly increased DALA-induced seizure activity. Similarly, blockade of MAO-B with deprenyl (3-48 mg/kg ip) also enhanced DALA-induced epileptiform pattern. It is evident from this study that MAO-B system significantly modulates the excitatory phenomena induced by DALA. These findings of interactions between MAO-B system and enkephalinergic one, might be of relevance in the clinical situations such as psychosis, stress, a use of tricyclic antidepressants and all other cases, where the alteration of MAO-B system is a part of disease or induced during drug therapy.


Jan 10, 1976·Lancet·M Sandler, G P Reynolds
May 13, 1978·Lancet·W M VerhoevenD de Wied
Oct 26, 1979·Science·S G PotkinR J Wyatt
Sep 1, 1977·Archives of General Psychiatry·N S KlineT Cooper
Apr 1, 1972·European Journal of Pharmacology·D BiegerO Hornykiewicz
Jul 1, 1968·Biochemical Pharmacology·J P Johnston
Jan 1, 1982·Brain Research Bulletin·M R Dzoljic, A L van der Poel-Heisterkamp
Nov 1, 1980·Neuropharmacology·R S SloviterE G Drust
Jul 1, 1980·Pharmacology, Biochemistry, and Behavior·M R Dzoljic, A L van der Poel-Heisterkamp

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Apr 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·O E UkponmwanM Dzoljic
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·C T Dourish, S J Cooper
Sep 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Wahl

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