PMID: 108709Feb 28, 1979

MAO inhibition and the effects of centrally administered LSD, serotonin, and 5-methoxytryptamine on the conditioned avoidance response in rats

W C Prozialeck, W H Vogel


Pretreatment with the MAO-inhibitors iproniazid, clorgyline, or deprenyl abolishes the effects of LSD on the conditioned avoidance response (CAR) in rats. The effects of serotonin (5-HT) and 5-methoxytryptamine (5-MT) are greatly potentiated by these substances. Brain levels of LSD are not affected by MAO inhibition whereas levels of 5-HT and 5-MT are significantly elevated. It is postulated that the decreased behavioral response to LSD is the result of 'MAO inhibitor-induced' changes whereas the increased response of 5-HT and 5-MT results from increased brain levels of these compounds.


Mar 1, 1981·International Journal of Biometeorology·J M Olivereau, J F Lambert
Dec 1, 1980·Psychological Reports·J F Lambert, J M Olivereau
Oct 1, 1987·Medical Hypotheses·M D Vincent

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