MAO inhibition by arylisopropylamines: the effect of oxygen substituents at the beta-position

Bioorganic & Medicinal Chemistry
Mauricio Osorio-OlivaresAngélica Fierro

Abstract

Twenty-nine arylisopropylamines, substituted at the beta-position of their side chain by an oxo, hydroxy, or methoxy group, were evaluated in vitro as MAO-A and MAO-B inhibitors. The oxo derivatives ('cathinones') were in general less active as MAO-A inhibitors than the corresponding arylisopropylamines, but exhibited an interesting MAO-B inhibiting activity, which was absent in the hydroxy, methoxy, and beta-unsubstituted analogues. These results suggest that selective affinity for the two MAO isoforms in this family of compounds is modulated not only by the aryl substitution pattern but also by the side-chain substituents on the arylalkylamine scaffold.

Citations

Dec 10, 2013·Archives of Toxicology·Maria João ValenteMárcia Carvalho
Feb 7, 2009·Forensic Science International : Synergy·R P Archer
May 9, 2012·Journal of Forensic Sciences·Oliver Locos, Dominic Reynolds
Jun 20, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anteneh M Feyissa, John P Kelly
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Feb 11, 2020·Frontiers in Pharmacology·Miguel Reyes-ParadaBruce K Cassels
Jun 9, 2021·Archives of Toxicology·Jorge SoaresJoão Paulo Capela

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