MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli

Scientific Reports
SeungYeong ImChang-Hun Lee

Abstract

Among the genetic variations in the monoamine oxidase A (MAOA) gene, upstream variable number tandem repeats (uVNTRs) of the promoter have been associated with individual differences in human physiology and aggressive behaviour. However, the evidence for a molecular or neural link between MAOA uVNTRs and aggression remains ambiguous. Additionally, the use of inconsistent promoter constructs in previous studies has added to the confusion. Therefore, it is necessary to demonstrate the genetic function of MAOA uVNTR and its effects on multiple aspects of aggression. Here, we identified three MAOA alleles in Koreans: the predominant 3.5R and 4.5R alleles, as well as the rare 2.5R allele. There was a minor difference in transcriptional efficiency between the 3.5R and 4.5R alleles, with the greatest value for the 2.5R allele, in contrast to existing research. Psychological indices of aggression did not differ among MAOA genotypes. However, our electroencephalogram and electrocardiogram results obtained under aggression-related stimulation revealed oscillatory changes as novel phenotypes that vary with the MAOA genotype. In particular, we observed prominent changes in frontal γ power and heart rate in 4.5R carriers of men. Our finding...Continue Reading

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Feb 20, 2021·Translational Psychiatry·Alexios-Fotios A MentisGeorge P Chrousos
Jun 8, 2021·Mechanisms of Ageing and Development·Cristina SanfilippoMichelino Di Rosa

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Datasets Mentioned

BETA
m89636

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BETA
transfection
PCR
genotyping
electrophoresis
Assay

Software Mentioned

Prism
BIOPAC AcqKnowledge
MATLAB

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