MAP kinase cascades regulating axon regeneration in C. elegans

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Strahil Iv PastuhovKunihiro Matsumoto

Abstract

Mitogen-activated protein kinase (MAPK) signaling cascades are activated by diverse stimuli such as growth factors, cytokines, neurotransmitters and various types of cellular stress. Our evolving understanding of these signal cascades has been facilitated by genetic analyses and physiological characterization in model organisms such as the nematode Caenorhabditis elegans. Genetic and biochemical studies in C. elegans have shed light on the physiological roles of MAPK cascades in the control of cell fate decision, neuronal function and immunity. Recently it was demonstrated that MAPK signaling is also important for axon regeneration in C. elegans, and the use of C. elegans as a model system has significantly advanced our understanding of the largely conserved molecular mechanisms underlying axon regeneration. This review summarizes our current understanding of the role and regulation of MAPK signaling in C. elegans axon regeneration.

References

Apr 1, 1997·Journal of Neurochemistry·C H ReynoldsB H Anderton
Jul 31, 1998·Nature·A CalignanoD Piomelli
Dec 2, 1999·Experimental Cell Research·J EnglishM H Cobb
Feb 10, 2000·Nature·R PrinjhaF S Walsh
Jul 27, 2002·Science·Dennis H KimFrederick M Ausubel
Jul 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dennis H KimFrederick M Ausubel
Sep 2, 2004·Nature Reviews. Drug Discovery·Vincenzo Di MarzoLuciano De Petrocellis
Dec 17, 2004·Nature·Mehmet Fatih YanikAdela Ben-Yakar
Apr 20, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Satoshi KishidaJun Ninomiya-Tsuji
Apr 19, 2006·The Journal of Cell Biology·Tatsiana TararukEleanor T Coffey
Jan 24, 2009·Science·Marc HammarlundMichael Bastiani
Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Monia BarnatFatiha Nothias
Oct 6, 2010·The Journal of Cell Biology·Xin XiongCatherine A Collins
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aki ItohTakayuki Itoh
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Paola NixMichael Bastiani
Dec 14, 2011·Trends in Neurosciences·Eun-Mi HurFeng-Quan Zhou
Feb 16, 2012·Nature Reviews. Neuroscience·Frank BradkeMicha E Spira

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Citations

Aug 22, 2016·Journal of Nanobiotechnology·Chiranjib ChakrabortySang-Soo Lee
Jan 24, 2017·Genetics·Andrew D ChisholmWilliam G Wadsworth
Sep 23, 2020·Molecular Neurobiology·Ambika ChandrasekharDouglas W Zochodne
Oct 18, 2020·International Journal of Molecular Sciences·Leo Veenman
Dec 12, 2020·Molecular Biology Reports·Sayan PaulSudhakar Sivasubramaniam
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chenyun GuoDonghai Lin
Apr 4, 2021·Nutrients·Guillaume CardinLaurent Rios

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BETA
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