MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes

Nature
T J HemesathDavid E Fisher

Abstract

Germline mutations at loci encoding the transcription factor Microphthalmia (Mi), the cytokine receptor c-Kit, or its ligand Steel factor (S1) result in strikingly similar defects in mast cell and melanocyte development. Here we describe a biochemical link between Kit signalling and the activity of Mi. Stimulation of melanoma cells with S1 results in activation of MAP kinase, which in turn phosphorylates Mi at a consensus target serine. This phosphorylation upregulates Mi transactivation of the tyrosinase pigmentation gene promoter. In addition to modulating pigment production, such signalling may regulate the expression of genes essential for melanocyte survival and development. The pathway represents a new application of the general MAP kinase machinery in transducing a signal between a tissue-specific receptor at the cell surface and a tissue-specific transcription factor in the nucleus.

References

Dec 1, 1992·Current Opinion in Cell Biology·N G AhnE G Krebs
Sep 11, 1990·Nucleic Acids Research·S Mizushima, S Nagata
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P DubreuilA Bernstein
Feb 1, 1989·Molecular and Cellular Biology·V P StantonG M Cooper
Jan 1, 1987·The International Journal of Biochemistry·V J Hearing, M Jiménez
Nov 1, 1995·Trends in Genetics : TIG·K J Moore
Apr 1, 1996·Current Opinion in Cell Biology·R Treisman

❮ Previous
Next ❯

Citations

Nov 9, 2000·European Journal of Immunology·B RuppA K Werenskiold
Sep 21, 2002·Microscopy Research and Technique·Ian K Quigley, David M Parichy
Jul 10, 2007·Archives of Pharmacal Research·Dong-Seok KimKyoung-Chan Park
Apr 20, 2004·Archives of Pharmacal Research·Dong-Seok KimKyoung-Chan Park
Feb 24, 2010·Clinical & Experimental Metastasis·József TímárErzsébet Rásó
May 28, 2013·Archives of Pharmacal Research·Seong Jin LeeHeeyeong Cho
Jun 17, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zeba N SinghVesna M Petronic-Rosic
Aug 4, 2011·Nature Communications·Xiansi ZhaoDavid E Fisher
Jul 25, 2006·Nature Reviews. Cancer·Levi A Garraway, William R Sellers
Feb 14, 2002·Pediatric Dermatology·C AngeloM Paradisi
Jan 8, 2010·The Journal of Biological Chemistry·Barbara BelleiMauro Picardo
Mar 21, 2012·The Journal of Biological Chemistry·Mariangela PucciMauro Maccarrone
Mar 28, 1998·The Journal of Experimental Medicine·K N WeilbaecherD E Fisher
Jan 13, 2009·Zebrafish·Craig J CeolLeonard I Zon
Jul 26, 2012·Carcinogenesis·Kin Lam FokHsiao Chang Chan
Aug 16, 2008·Nucleic Acids Research·C Claus StoltMichael Wegner
Feb 24, 2005·The American Journal of Surgical Pathology·Klaus J BusamAchim A Jungbluth
Jan 10, 2013·Current Opinion in Oncology·Lu Si, Jun Guo
May 23, 2008·The American Journal of Dermatopathology·Jarosław Jóźwiak, Ryszard Galus
Jun 2, 2010·The American Journal of Dermatopathology·L Frank GlassBasil S Cherpelis
Dec 29, 2007·The American Journal of Surgical Pathology·Mariana M CajaibaMiguel Reyes-Múgica
Mar 29, 2012·The Cancer Journal·Melissa Ann Wilson, Katherine L Nathanson
Jun 5, 2012·Genes & Development·Hensin TsaoDavid E Fisher
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·L A GarrawayW R Sellers
Jul 17, 2008·Pigment Cell & Melanoma Research·Satoru YokoyamaDavid E Fisher
Apr 9, 2010·Pigment Cell & Melanoma Research·Bin WenLing Hou
Jan 21, 2012·Pigment Cell & Melanoma Research·Vijay WaliaYardena Samuels
May 28, 2011·Science·Carmine SettembreAndrea Ballabio
Jun 21, 2001·Molecular and Cellular Biology·S BenkhelifaM P Felder-Schmittbuhl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.