MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer

Oncotarget
María-José de Miguel-LukenA Carnero

Abstract

Larynx cancer organ preservation treatments with chemo and radiotherapy have substantially improved laryngoesophageal dysfunction-free survival. However, both of them lead to a high incidence of acute and chronic toxicities and a significant number of patients relapse. To date, there is no evidence available to establish the group of patients that may benefit from preservation approaches and clinical criteria such as primary tumor extension or pretreatment tracheotomy are not validated. MAP17 is a small non-glycosylated membrane protein overexpressed in carcinomas. The tumoral behavior induced by MAP17 is associated with reactive oxygen species production in which SGLT1 seems involved. In this study we found that the levels of MAP17 were related to clinical findings and survival in a cohort of 58 patients with larynx cancer. MAP17 expression is associated with overall survival (p<0.001) and laryngoesophageal dysfunction-free survival (p=0.002). Locoregional control in patients with high MAP17 showed better outcomes than those with low MAP17 (p=0.016). Besides, a positive correlation was observed between MAP17 expression and SGLT (p=0.022) and the combination of high levels of MAP17/SGLT also led to an increased overall survival...Continue Reading

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Citations

Dec 13, 2017·Oncotarget·José M García-Heredia, Amancio Carnero
Aug 27, 2016·Oncotarget·Marco PerezAmancio Carnero
Mar 5, 2016·Cell Cycle·María José de Miguel-LukenAmancio Carnero
Feb 20, 2018·Experimental and Therapeutic Medicine·Qiong ZhangKun Yuan
Aug 19, 2018·Journal of Experimental & Clinical Cancer Research : CR·Irene FerrerAmancio Carnero
Apr 14, 2018·Molecular Cancer·José M García-Heredia, Amancio Carnero

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