Abstract
Plasticity in the central nervous system after cerebral ischemia is a controversial issue; focal cerebral ischemia produces an area of infarction that is surrounded by neurons that may respond to nearby damage by creating new synapses. In the present study the expression of the postsynaptic microtubule-associated protein 2 (MAP2) and the presynaptic marker protein, synaptophysin, was investigated by immunocytochemical techniques in the CA1 sector of hippocampus and in cerebellum of rats made ischemic by bilateral clamping of common carotid arteries and reperfused for 7 and 30 days. In addition, ischemia-induced behavioral alterations were also evaluated after 7 and 30 days of reperfusion. The present study demonstrates a decreased postsynaptic MAP2 immunoreactivity, representative of neuronal loss, particularly in CA1 sector of hippocampus and in cerebellum of ischemic rats reperfused for 7 days. After 30 days of reperfusion, MAP2 immunostaining was similar to control. In the same brain sections an increased presynaptic synaptophysin immunoreactivity has been observed only after 30 days of reperfusion. These data suggest compensatory regenerative changes associated with synaptic remodelling and are supported by behavioral recov...Continue Reading
Citations
Feb 22, 2011·Apoptosis : an International Journal on Programmed Cell Death·Weizhen Ye, Stacy W Blain
Jul 14, 2011·Neurotoxicity Research·B S ThippeswamyS Badami
Oct 26, 2013·European Journal of Pharmacology·G L ViswanathaC G Mohan
Jul 2, 2003·Brain Research·Masaki SekiguchiR S Nowakowski
Mar 17, 1999·Resuscitation·V A AkulininA Dahlström
Jan 4, 2001·Neuroscience Letters·I Antonow-SchlorkeM Schwab
Jan 9, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G MartinezA Vanella
Jul 20, 2010·Brain : a Journal of Neurology·Weizhen Ye, Stacy W Blain
Sep 26, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Claudia Di GiacomoFabio Galvano
Jan 27, 2005·Life Sciences·Sudhirkumar YanpallewarS B Acharya
Feb 3, 2005·Neurobiology of Disease·Jasna KrizKresimir Krnjević
Sep 24, 2004·Neuroscience·D L AdkinsT A Jones
Feb 19, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Carla LoretoGiuseppa Martinez
Jun 16, 2004·Neuroscience Letters·Claudia ColbergMatthias Schwab
May 13, 2006·Pediatric Research·Matteo BruschettiniHarry W M Steinbusch
Jun 9, 2016·Molecular Neurobiology·Ouafa NajybEric Rassart
Oct 24, 2017·Psychopharmacology·Xianzhi ShenXinchun Jin
Apr 12, 2002·Journal of Neuroscience Research·Ayalla Barnea, Jodie Roberts