MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping.

Age
Fausta Di CianniGiuseppina Rose

Abstract

The pathways that regulate energy homeostasis, the mechanisms of damage repair, and the signaling response to internal environmental changes or external signals have been shown to be critical in modulating lifespan of model organisms and humans. In order to investigate whether genetic variation of genes involved in these pathways contribute to longevity, a two-stage case-control study in two independent sets of long-lived individuals from Calabria (Italy) was performed. In stage 1, 317 SNPs in 104 genes were analyzed in 78 cases (median age 98 years) and 71 controls (median age 67 years). In stage 2, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (median age 92 years) and 554 controls (median age 67 years). Two SNPs, rs282070 located in intron 1 of the MAP3K7 gene, and rs2111699 located in intron 1 of the GSTZ1 gene, were significantly associated (after adjustment for multiple testing) with longevity in stage 2 (p = 1.1 × 10(-3) and p = 1.4 × 10(-3), respectively). Interestingly, both genes are implicated in the cellular response to internal and external environmental changes, playing a crucial role in the inflammation processes that accompany aging. Our da...Continue Reading

References

Nov 21, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·B LjungquistN L Pedersen
Oct 20, 2000·European Journal of Human Genetics : EJHG·H GudmundssonK Stefánsson
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R A KerberR M Cawthon
May 4, 2001·Trends in Genetics : TIG·A Cournil, T B Kirkwood
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·A A PucaT Perls
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Thomas T PerlsAnnibale Puca
May 6, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dellara F TerryThomas T Perls
Aug 14, 2003·Genetic Epidemiology·Jaya M Satagopan, Robert C Elston
Nov 20, 2003·Twin Research : the Official Journal of the International Society for Twin Studies·Axel SkyttheKaare Christensen
Apr 9, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dellara F TerryThomas T Perls
Oct 8, 2004·Journal of Biochemistry and Molecular Biology·Jong-Min Lee, Jeffrey A Johnson
Nov 16, 2004·Genetic Epidemiology·Duncan ThomasMulugeta Gebregziabher
Dec 21, 2004·Human Genomics·Daniel W Nebert, Vasilis Vasiliou
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·John D HayesIan R Jowsey
Sep 28, 2005·Nature Immunology·Shintaro SatoShizuo Akira
Oct 26, 2005·Nature Genetics·Paul I W de BakkerDavid Altshuler
Oct 28, 2005·European Journal of Human Genetics : EJHG·Manja SchoenmakerRudi G J Westendorp
Jan 10, 2006·Methods in Enzymology·Philip G Board, M W Anders
Feb 8, 2006·Human Genetics·Jacob vB HjelmborgKaare Christensen
Feb 18, 2006·Cell Death and Differentiation·Z J ChenR B Seth
Apr 14, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Bradley J WillcoxMakoto Suzuki
Apr 21, 2006·Genetics·Yijun ZuoHongyu Zhao
May 19, 2006·Nature Reviews. Genetics·Kaare ChristensenJames W Vaupel
Nov 25, 2006·Human Heredity·Giuseppe PassarinoGiovanna De Benedictis
Jun 6, 2007·Genetic Epidemiology·Andrew D SkolMichael Boehnke
May 10, 2008·BMC Proceedings·Gang ZhengNancy L Geller
Jun 24, 2008·Statistics in Medicine·Gang ZhengYaning Yang
Jul 9, 2008·The Journal of Biological Chemistry·Emily OmoriJun Ninomiya-Tsuji
Jul 17, 2008·Psychiatric Genetics·John M StarrLawrence J Whalley
Nov 26, 2008·Molecular and Cellular Endocrinology·Massimiliano Bonafè, Fabiola Olivieri
Apr 10, 2009·Current Medicinal Chemistry·Junichi MaruyamaHidenori Ichijo
Jun 6, 2009·Aging Cell·Ludmila PawlikowskaUNKNOWN Study of Osteoporotic Fractures
Aug 25, 2009·Mechanisms of Ageing and Development·Almut NebelStefan Schreiber
Sep 17, 2009·Current Pharmaceutical Design·Mónica De la Fuente, Jaime Miquel
Sep 24, 2009·BMC Medical Genetics·Roser CorominasAlfons Macaya
Jan 12, 2010·The International Journal of Biochemistry & Cell Biology·Marene Landström
Jan 19, 2010·Biochimica Et Biophysica Acta·Eun Kyung Kim, Eui-Ju Choi
Mar 23, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anne B NewmanJoanne M Murabito

❮ Previous
Next ❯

Citations

Aug 24, 2013·International Journal of Molecular Sciences·Serena DatoGiuseppe Passarino
Nov 18, 2018·Redox Report : Communications in Free Radical Research·Shangfu XuLili Ji
Jul 22, 2019·Genes·Giusi TaorminaMario G Mirisola
Jan 17, 2020·Critical Reviews in Toxicology·Patrick E Hanna, M W Anders

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.