MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation

The Journal of Immunology : Official Journal of the American Association of Immunologists
Søren E DegnSteffen Thiel

Abstract

Essential effector functions of innate immunity are mediated by complement activation initiated by soluble pattern recognition molecules: mannan-binding lectin (MBL) and the ficolins. We present a novel, phylogenetically conserved protein, MAp44, which is found in human serum at 1.4 microg/ml in Ca(2+)-dependent complexes with the soluble pattern recognition molecules. The affinity for MBL is in the nanomolar range (K(D) = 0.6 nM) as determined by surface plasmon resonance. The first eight exons of the gene for MAp44 encode four domains shared with MBL-associated serine protease (MASP)-1 and MASP-3 (CUB1-EGF-CUB2-CCP1), and a ninth exon encodes C-terminal 17 aa unique to MAp44. mRNA profiling in human tissues shows high expression in the heart. MAp44 competes with MASP-2 for binding to MBL and ficolins, resulting in inhibition of complement activation. Our results add a novel mechanism to those known to control the innate immune system.

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R BreathnachP Chambon
May 8, 1999·Gene·J E Tabaska, M Q Zhang
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M MatsushitaT Fujita
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S ThielJ C Jensenius
Jul 13, 2000·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Z ZhangW Miller
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T Vorup-JensenJ C Jensenius
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M MatsushitaT Fujita
Mar 21, 2001·Molecular Immunology·S V PetersenJ C Jensenius
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N M ThielensG J Arlaud
Nov 1, 2001·Journal of Immunological Methods·S V PetersenJ C Jensenius
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Misao MatsushitaTeizo Fujita
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandor CsehNicole M Thielens
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert L StrausbergUNKNOWN Mammalian Gene Collection Program Team
Jan 14, 2003·Annual Review of Immunology·Uffe HolmskovJens C Jensenius
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuichi EndoTeizo Fujita
Jul 31, 2003·Biochemical Society Transactions·J C JenseniusS Thiel
Nov 8, 2003·Journal of Immunological Methods·Mette Møller-KristensenSteffen Thiel
Apr 3, 2004·The Journal of Biological Chemistry·Ce-Belle Chen, Russell Wallis
Jun 18, 2004·Immunological Reviews·Masaru Nonaka, Fumiko Yoshizaki
Sep 30, 2004·Nature Immunology·Michael C Carroll
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas J LynchWilhelm J Schwaeble
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu LiuTeizo Fujita
Nov 25, 2005·Scandinavian Journal of Immunology·P D FrederiksenJ C Jensenius
Aug 10, 2006·Immunogenetics·Masaru Nonaka, Ayuko Kimura
Nov 18, 2006·Nature Immunology·Philippe J Sansonetti
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daisuke IwakiTeizo Fujita
Dec 22, 2006·International Immunology·Mette Møller-KristensenJens C Jensenius
Sep 12, 2007·Bioinformatics·M A LarkinD G Higgins
Nov 15, 2007·Nucleic Acids Research·P FlicekS Searle
Jun 20, 2008·Nature·Nicholas H PutnamDaniel S Rokhsar

❮ Previous
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Citations

Jan 25, 2011·Nature Genetics·Caroline RooryckPhilip L Beales
Jun 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Dávid HéjaPéter Gál
Jan 13, 2012·The Journal of Biological Chemistry·Rikke M ZachoSteffen Thiel
Sep 7, 2011·Journal of Biochemistry·Takayuki YoshizakiNobutaka Wakamiya
May 24, 2012·Journal of Biomedicine & Biotechnology·Maciej CedzynskiDavid C Kilpatrick
Sep 12, 2013·PloS One·Christian Gytz AmmitzbøllJens Christian Jensenius
Feb 5, 2013·The Journal of Biological Chemistry·Christel R BrinkmannSøren E Degn
Jun 18, 2015·Frontiers in Immunology·Nicolas S MerleLubka T Roumenina
Feb 6, 2015·Frontiers in Pediatrics·Marcia Holsbach BeltrameIara José de Messias-Reason
Sep 28, 2014·Cancer Immunology, Immunotherapy : CII·Line StormUNKNOWN Danish Study Group on Early Detection of Colorectal Cancer
Jun 15, 2011·American Journal of Human Genetics·Søren E DegnSteffen Thiel
Jan 30, 2014·Molecular Immunology·Márton MegyeriPéter Gál
Feb 22, 2017·Blood Reviews·Andrea C Baines, Robert A Brodsky
Mar 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon A MortensenSøren E Degn
Sep 19, 2017·Nature Reviews. Immunology·Edimara S ReisJohn D Lambris
Jun 30, 2016·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Olivia K GardnerPedro A Sanchez-Lara
Jan 23, 2016·Immunogenetics·Helga BjarnadottirBjorn Runar Ludviksson
Jun 17, 2018·The Journal of Rheumatology·Anne TroldborgKristian Stengaard-Pedersen
May 16, 2013·Scandinavian Journal of Immunology·S E Degn, S Thiel
Oct 23, 2015·The EMBO Journal·Goran BajicGregers R Andersen
Aug 11, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manabu HayashiHideharu Sekine
Aug 31, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura Pérez-AlósPeter Garred
Oct 1, 2015·Orphanet Journal of Rare Diseases·Tahir AtikMustafa Tekin
Dec 15, 2010·Current Opinion in Organ Transplantation·Søren E DegnMette Bjerre
Apr 3, 2020·PLoS Neglected Tropical Diseases·Hellen Weinschutz MendesIara J Taborda Messias-Reason
Aug 12, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mie Anemone NordmajPeter Garred
Feb 12, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sadam YaseenWilhelm J Schwaeble
Apr 9, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Misao MatsushitaTeizo Fujita
Jul 30, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nirmal K BandaV Michael Holers
Jan 21, 2016·American Journal of Medical Genetics. Part a·Jill UrquhartJill Clayton-Smith

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