MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges

Frontiers in Cell and Developmental Biology
Matthias Gaestel

Abstract

Downstream of MAPKs, such as classical/atypical ERKs and p38 MAPKs, but not of JNKs, signaling is often mediated by protein kinases which are phosphorylated and activated by MAPKs and, therefore, designated MAPK-activated protein kinases (MAPKAPKs). Recently, novel insights into the specificity of the assembly of MAPK/MAPKAPK hetero-dimeric protein kinase signaling complexes have been gained. In addition, new functional aspects of MKs have been described and established functions have been challenged. This short review will summarize recent developments including the linear motif (LM) in MKs, the ERK-independent activation of RSK, the RSK-independent effects of some RSK-inhibitors and the challenged role of MK5/PRAK in tumor suppression.

References

Jun 17, 1998·The EMBO Journal·L NewJ Han
May 13, 1999·The Journal of Biological Chemistry·O HeidenreichA Nordheim
Jun 8, 2002·Molecular and Cellular Biology·Alexey KotlyarovMatthias Gaestel
Jun 17, 2003·Molecular Biology of the Cell·Liguo NewJiahuai Han
Oct 16, 2003·Molecular and Cellular Biology·Yu ShiMatthias Gaestel
Aug 4, 2004·Biochemistry·Susan M LukasBrian G Werneburg
Oct 4, 2005·Biochemical and Biophysical Research Communications·Tatsuhiko SudoHiroyuki Osada
Jan 20, 2006·Nature Reviews. Molecular Cell Biology·Matthias Gaestel
Sep 15, 2006·The Journal of Biological Chemistry·Espen AbergOle-Morten Seternes
Mar 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andre WhiteBennett T Farmer
Sep 14, 2007·The Biochemical Journal·Jenny BainPhilip Cohen
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Matthias Gaestel
May 29, 2009·The Journal of Biological Chemistry·Espen AbergOle-Morten Seternes
Aug 21, 2010·The Journal of Biological Chemistry·Manoj B MenonMatthias Gaestel
Feb 15, 2011·The Journal of Biological Chemistry·Alina De la Mota-PeynadoAlexander Beeser
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Marie Cargnello, Philippe P Roux
Nov 30, 2011·Molecular and Cellular Biology·Naoto YoshizukaPeiqing Sun
Jul 24, 2013·The Journal of Experimental Medicine·Kwan T ChowMark S Schlissel
Mar 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Anita AlexaAttila Reményi
Aug 14, 2015·Journal of Medicinal Chemistry·Rama JainCynthia M Shafer

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Citations

Mar 2, 2018·International Journal of Molecular Sciences·Jaroslav KalousAndrej Susor
Aug 10, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Liya ZhuByeong-Cheol Ahn
Aug 15, 2018·Molecular Medicine Reports·Yang LiZhao Hu
Mar 1, 2019·International Journal of Molecular Medicine·Li-Ya DongSong Xue
Jul 1, 2020·Archives of Virology·Alicja WarowickaAnna Goździcka-Józefiak
Jun 23, 2020·Biochemistry. Biokhimii︠a︡·B A Reikhardt, P D Shabanov
Nov 6, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Shuaishuai HuangYu Ren
Jul 3, 2021·International Journal of Molecular Sciences·Ting LiChangmin Hu
Jul 10, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shuang LiuPing Xin
Aug 26, 2021·Technology in Cancer Research & Treatment·Peng HuangLinjiang Song
Jul 11, 2020·Structure·Péter SokAttila Reményi

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Methods Mentioned

BETA
acetylation

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